felodipine vs itraconazole
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Side-by-side comparison of felodipine and itraconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Calcium Channel Blockers Felodipine a Nisoldipine Contraindicated during and 2 weeks after itraconazole treatment.
Plendil
Sporanox
Felodipine is a drug that lowers your blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Itraconazole capsules are an antifungal medicine. They treat fungal infections in your body.
Felodipine treats high blood pressure (hypertension). Lowering your blood pressure helps prevent strokes and heart attacks. It's important to also manage other risk factors like cholesterol, diabetes, and smoking. You may need more than one medicine to control your blood pressure.
Itraconazole treats fungal infections like blastomycosis, histoplasmosis, and aspergillosis. It can help both people with healthy immune systems and those with weakened immune systems. It also treats onychomycosis, a fungal infection of the toenails or fingernails.
Felodipine is a calcium channel blocker. It works by relaxing and widening your blood vessels. This makes it easier for blood to flow, which lowers blood pressure.
Itraconazole stops fungi from growing. It does this by interfering with the production of a substance fungi need to build their cell membranes. This eventually kills the fungus and clears the infection.
- • Swelling in your ankles or feet
- • Headache
- • Flushing (redness of face)
- • Feeling tired
- • Nausea
- • Rash
- • Headache
- Fatigue 1,051
- Dyspnoea 952
- Dizziness 946
- Diarrhoea 846
- Nausea 846
- Drug Interaction 1,118
- Pyrexia 568
- Dyspnoea 474
- Pneumonia 461
- Nausea 445
If you take certain medicines like ketoconazole, itraconazole, or erythromycin, talk to your doctor. These drugs can greatly increase the amount of felodipine in your blood, leading to unwanted effects. Also, if you take anticonvulsants like phenytoin, carbamazepine, or phenobarbital, felodipine may not work as well.
Itraconazole can cause congestive heart failure. You should not take this medicine if you have heart problems. Itraconazole can also interact with many other medicines. Some of these interactions can be dangerous or even fatal. Check with your doctor about all the medicines you take.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if felodipine will harm your unborn baby. Talk to your doctor about breastfeeding while taking felodipine.
You should not take itraconazole if you are pregnant or plan to become pregnant. It can harm your unborn baby. Talk to your doctor about safe alternatives.
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How to Read This felodipine vs itraconazole Comparison
felodipine is classified in the Calcium Channel Blocker drug class, while itraconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, felodipine has 4,641 submissions while itraconazole has 3,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to itraconazole stops the body from breaking down felodipine, which can lead to dangerously high levels of the blood pressure medicine in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for felodipine or itraconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.