Famotidine and Itraconazole Interaction
Drug interaction information between Famotidine and Itraconazole.
Famotidine and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Famotidine and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Famotidine reduces stomach acid, which is needed for the body to properly absorb itraconazole.
FDA Label Information
See the prescribing information for other drugs dependent on gastric pH for absorption for administration instructions, including atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, and rilpivirine.
Famotidine Also Interacts With
- Theophylline major
- Tizanidine moderate
- Ketoconazole minor
- Ledipasvir/Sofosbuvir minor
- Aripiprazole minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Famotidine + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Famotidine's 11. In the minor band specifically: Famotidine has 9 (also Ketoconazole, Ledipasvir/Sofosbuvir, Aripiprazole, Cidofovir); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Famotidine and Itraconazole?
Famotidine reduces stomach acid, which is needed for the body to properly absorb itraconazole.
Itraconazole carries more major-labeled pairs than Famotidine
SPL source-record counts only. This page's band is minor · classes on file: Famotidine (H2 Receptor Antagonist); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Famotidine's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 9 minor · 11 total
- Other minor peers for Famotidine
- Ketoconazole
- Ledipasvir/Sofosbuvir
- Aripiprazole
- Cidofovir
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.