Famotidine and Aripiprazole Interaction
Drug interaction information between Famotidine and Aripiprazole.
Famotidine and Aripiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Famotidine and Aripiprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs do not significantly change how the body processes or removes each other.
FDA Label Information
7.2 Drugs Having No Clinically Important Interactions with Aripiprazole Based on pharmacokinetic studies, no dosage adjustment of aripiprazole is required when administered concomitantly with famotidine, valproate, lithium, lorazepam.
Famotidine Also Interacts With
- Theophylline major
- Tizanidine moderate
- Ketoconazole minor
- Ledipasvir/Sofosbuvir minor
- Itraconazole minor
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Venlafaxine minor
Frequently Asked Questions
What SPL severity band is on file for Famotidine + Aripiprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aripiprazole has 19 labeled pairs on file vs Famotidine's 11. In the minor band specifically: Famotidine has 9 (also Ketoconazole, Ledipasvir/Sofosbuvir, Itraconazole, Cidofovir); Aripiprazole has 19 (also Omeprazole, Sertraline, Escitalopram, Fluoxetine).
What mechanism field is on file for Famotidine and Aripiprazole?
These two drugs do not significantly change how the body processes or removes each other.
Famotidine carries more major-labeled pairs than Aripiprazole
SPL source-record counts only. This page's band is minor · classes on file: Famotidine (H2 Receptor Antagonist); Aripiprazole (Atypical Antipsychotic).
Famotidine has 1 major-labeled pair vs Aripiprazole's 0. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 9 minor · 11 total
- Other minor peers for Famotidine
- Ketoconazole
- Ledipasvir/Sofosbuvir
- Itraconazole
- Cidofovir
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Sertraline
- Escitalopram
- Fluoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.