Famotidine and Ledipasvir/Sofosbuvir Interaction
Drug interaction information between Famotidine and Ledipasvir/Sofosbuvir.
Famotidine and Ledipasvir/Sofosbuvir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Famotidine and Ledipasvir/Sofosbuvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Famotidine lowers stomach acid, which can make it harder for the body to absorb ledipasvir/sofosbuvir.
FDA Label Information
See the prescribing information for other drugs dependent on gastric pH for absorption for administration instructions, including atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, and rilpivirine.
Famotidine Also Interacts With
- Theophylline major
- Tizanidine moderate
- Ketoconazole minor
- Itraconazole minor
- Aripiprazole minor
Ledipasvir/Sofosbuvir Also Interacts With
- Atorvastatin moderate
- Rifampin moderate
- Amiodarone moderate
- Rosuvastatin moderate
- Rosuvastatin/Ezetimibe moderate
Frequently Asked Questions
What SPL severity band is on file for Famotidine + Ledipasvir/Sofosbuvir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ledipasvir/Sofosbuvir has 22 labeled pairs on file vs Famotidine's 11. In the minor band specifically: Famotidine has 9 (also Ketoconazole, Itraconazole, Aripiprazole, Cidofovir); Ledipasvir/Sofosbuvir has 17 (also Omeprazole, Pravastatin, Warfarin, Verapamil).
What mechanism field is on file for Famotidine and Ledipasvir/Sofosbuvir?
Famotidine lowers stomach acid, which can make it harder for the body to absorb ledipasvir/sofosbuvir.
Famotidine carries more major-labeled pairs than Ledipasvir/Sofosbuvir
SPL source-record counts only. This page's band is minor · classes on file: Famotidine (H2 Receptor Antagonist); Ledipasvir/Sofosbuvir (NS5A/NS5B Inhibitor (HCV)).
Famotidine has 1 major-labeled pair vs Ledipasvir/Sofosbuvir's 0. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 9 minor · 11 total
- Other minor peers for Famotidine
- Ketoconazole
- Itraconazole
- Aripiprazole
- Cidofovir
0 major · 5 moderate · 17 minor · 22 total
- Other minor peers for Ledipasvir/Sofosbuvir
- Omeprazole
- Pravastatin
- Warfarin
- Verapamil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.