What the FDA labels say about taking them together
Famotidine and ledipasvir/sofosbuvir
Famotidine's FDA label of February 6, 2026 names ledipasvir/sofosbuvir in its drug interactions (prescription label) section, and ledipasvir/sofosbuvir's label names famotidine too. The ledipasvir/sofosbuvir label: “H 2 -receptor antagonists may be administered simultaneously with or 12 hours apart from HARVONI at a dose that does not exceed doses comparable to famotidine 40 mg twice daily.”
Check it at the source: the famotidine FDA label on DailyMed (effective February 6, 2026, Kenvue Brands LLC); the ledipasvir/sofosbuvir FDA label on DailyMed (effective December 26, 2024, Gilead Sciences, Inc).
What does the famotidine label say about ledipasvir/sofosbuvir?
Famotidine label, drug interactions (prescription label)See the prescribing information for other drugs dependent on gastric pH for absorption for administration instructions, including atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, and rilpivirine.
Source: FDA drug label (Pepcid AC Original Strength), Kenvue Brands LLC, effective February 6, 2026 (SPL set 54f4086f-e443-4e7e-8c7e-94e152e1c256), via openFDA; the full label on DailyMed
What does the ledipasvir/sofosbuvir label say about famotidine?
Ledipasvir/sofosbuvir label, drug interactionsConcomitant Drug Class/Drug Name: H 2 -receptor antagonists These interactions have been studied in healthy adults. (e.g., famotidine); Effect on Concentration ↓ = decrease, ↑ = increase: ↓ ledipasvir; Clinical Comment: H 2 -receptor antagonists may be administered simultaneously with or 12 hours apart from HARVONI at a dose that does not exceed doses comparable to famotidine 40 mg twice daily.
Source: FDA drug label (Harvoni), Gilead Sciences, Inc, effective December 26, 2024 (SPL set f4ec77e4-bae8-4db0-b3d5-bde09c5fa075), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Famotidine | Ledipasvir/sofosbuvir | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Hepatitis C |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0289 per tablet 20 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once