Ezetimibe/Simvastatin and Ezetimibe Interaction
Drug interaction information between Ezetimibe/Simvastatin and Ezetimibe.
Ezetimibe/Simvastatin and Ezetimibe have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ezetimibe/Simvastatin and Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these drugs together can increase the levels of ezetimibe in your body. This combination might also increase the risk of developing gallstones.
FDA Label Information
( 2.3 , 7.1 ) Cholestyramine: Combination decreases exposure of ezetimibe. ( 7.3 ) Fenofibrates: Combination increases exposure of ezetimibe. If cholelithiasis is suspected in a patient receiving ezetimibe and a fenofibrate, gallbladder studies are indicated and alternative lipid-lowering therapy should be considered.
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Ezetimibe?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe has 25 labeled pairs on file vs Ezetimibe/Simvastatin's 23. In the minor band specifically: Ezetimibe/Simvastatin has 11 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin); Ezetimibe has 13 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Ezetimibe/Simvastatin and Ezetimibe?
Using these drugs together can increase the levels of ezetimibe in your body. This combination might also increase the risk of developing gallstones.
Ezetimibe's labeled portfolio outnumbers Ezetimibe/Simvastatin
SPL source-record counts only. This page's band is minor · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Ezetimibe (Cholesterol Absorption Inhibitor).
8 major · 4 moderate · 11 minor · 23 total
- Other minor peers for Ezetimibe/Simvastatin
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
8 major · 4 moderate · 13 minor · 25 total
- Other minor peers for Ezetimibe
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.