Ezetimibe/Simvastatin and Dronedarone Interaction
Drug interaction information between Ezetimibe/Simvastatin and Dronedarone.
Ezetimibe/Simvastatin and Dronedarone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Ezetimibe/Simvastatin and Dronedarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dronedarone interferes with how your body breaks down simvastatin, leading to higher drug levels and a greater risk of muscle damage.
FDA Label Information
Amiodarone, Dronedarone, Ranolazine, or Calcium Channel Blockers Clinical Impact: The risk of myopathy and rhabdomyolysis is increased by concomitant use of amiodarone, dronedarone, ranolazine, or calcium channel blockers with VYTORIN. Intervention: For patients taking verapamil, diltiazem, or dronedarone, do not exceed VYTORIN 10/10 mg daily.
Ezetimibe/Simvastatin Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Darunavir major
- Ezetimibe major
Frequently Asked Questions
What SPL severity band is on file for Ezetimibe/Simvastatin + Dronedarone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe/Simvastatin has 23 labeled pairs on file vs Dronedarone's 22. In the major band specifically: Ezetimibe/Simvastatin has 8 (also Amlodipine, Diltiazem, Verapamil, Cyclosporine); Dronedarone has 9 (also Ketoconazole, Clarithromycin, Voriconazole, Darunavir).
What mechanism field is on file for Ezetimibe/Simvastatin and Dronedarone?
Dronedarone interferes with how your body breaks down simvastatin, leading to higher drug levels and a greater risk of muscle damage.
Dronedarone carries more major-labeled pairs than Ezetimibe/Simvastatin
SPL source-record counts only. This page's band is major · classes on file: Ezetimibe/Simvastatin (Cholesterol Absorption Inhibitor / Statin Combination); Dronedarone (Class III Antiarrhythmic).
Dronedarone has 9 major-labeled pairs vs Ezetimibe/Simvastatin's 8.
8 major · 4 moderate · 11 minor · 23 total
- Other major peers for Ezetimibe/Simvastatin
- Amlodipine
- Diltiazem
- Verapamil
- Cyclosporine
9 major · 5 moderate · 8 minor · 22 total
- Other major peers for Dronedarone
- Ketoconazole
- Clarithromycin
- Voriconazole
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.