Prescription medication · Mineralocorticoid

fludrocortisone

Also sold as Florinef. This medicine is used to treat Addison's disease and salt-losing adrenogenital syndrome.

Data updated 2026-05-15

1,195
FDA reports
6
InteractionsFew interactions
$0.35
Generic price (NADAC)

What the data shows

fludrocortisone (Florinef) is a prescription Mineralocorticoid, with 1,195 FDA adverse-event reports on file, with 6 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

fludrocortisone (Florinef) is a prescription Mineralocorticoid. This medicine is used to treat Addison's disease and salt-losing adrenogenital syndrome.

Fludrocortisone is a medicine that helps your body balance salt and fluids. It is used when your adrenal glands don't make enough of certain hormones.

Verify with FDA → · CMS NADAC pricing →

Drug Pricing (NADAC)

Generic Price

$0.35/unit

Generic Available

Yes (3 manufacturers)

Pricing data from NADAC (CMS), effective December 25, 2024. Compare all drug costs →

NADAC price trail: FLUDROCORTISONE 0.1 MG TABLET

Same CMS presentation as the headline generic unit price above (2 effective dates). Adjacent % compares consecutive NADAC releases for this description only, not a patient out-of-pocket quote. Latest step: 0% vs prior release.

Effective NADAC / unit vs prior NDCs
December 18, 2024 $0.3549/EA - 11
December 25, 2024 $0.3549/EA 0% 2
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What it does

This medicine is used to treat Addison's disease and salt-losing adrenogenital syndrome.

Common side effects

High blood pressure, Swelling in your hands, feet, or ankles, Enlarged heart

Key warnings

This medicine may cause you to retain too much sodium and water, leading to high blood pressure, swelling, and heart problems.

The sections below are summarized in plain English from fludrocortisone's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Fludrocortisone is a mineralocorticoid. It works by helping your body to retain sodium and water. This helps to increase blood volume and blood pressure.

Side Effects (from patient reports)

Based on 1,195 FDA adverse event reports.

Most-reported reactions

Adverse reactions in FAERS for fludrocortisone, by number of reports

reports

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Source FDA Adverse Event Reporting System (FAERS)

Serious Warnings

This medicine may cause you to retain too much sodium and water, leading to high blood pressure, swelling, and heart problems. Tell your doctor right away if you have any of these symptoms. This medicine can also interact with other medicines, so be sure to tell your doctor about all the medicines you are taking.

Known Drug Interactions

minor furosemide

Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide) – enhanced hypokalemia.

Mechanism: Both drugs cause your body to lose potassium through your urine, which can lead to dangerously low levels of this important mineral.

minor aspirin

Aspirin – increased ulcerogenic effect; decreased pharmacologic effect of aspirin. Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. Monitor salicylate levels or the therapeutic effect for which aspirin is given; adjust salicylate dosage accordingly if effect is altered (see PRECAUTIONS, General ).

Mechanism: Taking these together increases the risk of stomach ulcers and can make aspirin less effective. If you stop the steroid suddenly, aspirin levels in your blood could rise to unsafe levels.

minor rifampin

Barbiturates, phenytoin, or rifampin – increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes.

Mechanism: Rifampin causes your liver to break down fludrocortisone much faster than normal. This makes the fludrocortisone less effective in your body.

minor amphotericin B

Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide) – enhanced hypokalemia.

Mechanism: Both of these medications can cause your body to lose potassium. Taking them together increases the risk of your potassium levels becoming dangerously low.

minor ethacrynic acid

Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide) – enhanced hypokalemia.

Mechanism: Both drugs cause the body to get rid of potassium through the urine. This can lead to very low potassium levels in your blood.

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This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.

Common Questions

What should I do if I experience side effects?
Tell your doctor about any side effects you experience while taking this medicine.
Can I take this medicine with other medications?
Tell your doctor about all the medicines you are taking, including over-the-counter drugs and supplements.
How often will I see the doctor while taking this medicine?
Your doctor will want to see you regularly to monitor your condition and adjust your dosage if needed.
What are the symptoms of low potassium?
Symptoms of low potassium can include muscle weakness, cramps, and irregular heartbeat.
Can this medicine affect my blood sugar?
Yes, this medicine can increase your blood sugar levels.
Will this medicine affect my bones?
Long-term use of this medicine can weaken your bones.
Can I stop taking this medicine suddenly?
No, do not stop taking this medicine suddenly without talking to your doctor.
What should I do if I am going to have surgery?
Tell your doctor that you are taking this medicine before any surgery.
Does this medicine interact with alcohol?
It is best to avoid alcohol while taking this medicine.
What if the blister pack is broken?
Do not use the medicine if the blister pack is torn or broken.
What are the common side effects of fludrocortisone?
The registry lists High blood pressure, Swelling in your hands, feet, or ankles, Enlarged heart, Heart failure, Loss of potassium among the most-reported FAERS reaction terms for fludrocortisone. The compiled record contains 1,195 FDA adverse-event reports. These counts are not an individual symptom assessment.
Does fludrocortisone interact with other medications?
The registry has 6 documented interaction rows for fludrocortisone. Notable source-record pairings include furosemide, aspirin, rifampin. These rows are not a complete medication review.
What drug class is fludrocortisone?
fludrocortisone belongs to the Mineralocorticoid drug class. It requires a prescription (Rx). This medicine is used to treat Addison's disease and salt-losing adrenogenital syndrome.
What pregnancy or breastfeeding source fields are listed for fludrocortisone?
The FDA label for fludrocortisone contains product-specific pregnancy or breastfeeding language. PlainMeds does not apply that source text to an individual.

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What the FDA Data Shows for fludrocortisone

The FDA label for fludrocortisone (sold under brand names such as Florinef) classifies it as a prescription-only medication in the Mineralocorticoid class. This medicine is used to treat Addison's disease and salt-losing adrenogenital syndrome. Official labeling lists 6 commonly reported side effects, including High blood pressure, Swelling in your hands, feet, or ankles, Enlarged heart.

Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,195 voluntary reports. The database also lists 6 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $0.35.

Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.

Data Sources

Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).

FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.

Last updated: May 19, 2025

PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.

Read our methodology - how this data is sourced, computed, and verified.

Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.

All federal data sources used on this page