Fludrocortisone and Furosemide Interaction
Drug interaction information between Fludrocortisone and Furosemide.
Fludrocortisone and Furosemide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fludrocortisone and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs cause your body to lose potassium through your urine, which can lead to dangerously low levels of this important mineral.
FDA Label Information
Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide) – enhanced hypokalemia.
Fludrocortisone Also Interacts With
- Aspirin minor
- Rifampin minor
- Amphotericin B minor
- Ethacrynic Acid minor
- Phenytoin minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Fludrocortisone + Furosemide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Fludrocortisone's 6. In the minor band specifically: Fludrocortisone has 6 (also Aspirin, Rifampin, Amphotericin B, Ethacrynic Acid); Furosemide has 29 (also Methotrexate, Norepinephrine, Ethacrynic Acid, Indomethacin).
What mechanism field is on file for Fludrocortisone and Furosemide?
Both drugs cause your body to lose potassium through your urine, which can lead to dangerously low levels of this important mineral.
Furosemide carries more major-labeled pairs than Fludrocortisone
SPL source-record counts only. This page's band is minor · classes on file: Fludrocortisone (Mineralocorticoid); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Fludrocortisone's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Fludrocortisone
- Aspirin
- Rifampin
- Amphotericin B
- Ethacrynic Acid
3 major · 4 moderate · 29 minor · 36 total
- Other minor peers for Furosemide
- Methotrexate
- Norepinephrine
- Ethacrynic Acid
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.