What the FDA labels say about taking them together
Fludrocortisone and furosemide
Fludrocortisone's FDA label of October 29, 2024 names furosemide in its drug interactions section; the furosemide labels PlainMeds reads (4) do not name fludrocortisone.
Check it at the source: the fludrocortisone FDA label on DailyMed (effective October 29, 2024, Zydus Lifesciences Limited); the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC).
What does the fludrocortisone label say about furosemide?
Fludrocortisone label, drug interactionsAmphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)–enhanced hypokalemia.
Source: FDA drug label (Fludrocortisone acetate), Zydus Lifesciences Limited, effective October 29, 2024 (SPL set 6c4a7d2d-00a4-4d80-ab4c-2afd4e4f614e), via openFDA; the full label on DailyMed
What does the furosemide label say about fludrocortisone?
Furosemide's label (effective September 30, 2025) and its 3 other brand-application labels do not name fludrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fludrocortisone | Furosemide | |
|---|---|---|
| Labeled for | n/a | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.311 per tablet 0.1 mg tablet | $0.490 per mL 20 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once