Fludrocortisone and Rifampin Interaction
Drug interaction information between Fludrocortisone and Rifampin.
Fludrocortisone and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fludrocortisone and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your liver to break down fludrocortisone much faster than normal. This makes the fludrocortisone less effective in your body.
FDA Label Information
Barbiturates, phenytoin, or rifampin – increased metabolic clearance of fludrocortisone acetate because of the induction of hepatic enzymes.
Fludrocortisone Also Interacts With
- Furosemide minor
- Aspirin minor
- Amphotericin B minor
- Ethacrynic Acid minor
- Phenytoin minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Fludrocortisone + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Fludrocortisone's 6. In the minor band specifically: Fludrocortisone has 6 (also Furosemide, Aspirin, Amphotericin B, Ethacrynic Acid); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Fludrocortisone and Rifampin?
Rifampin causes your liver to break down fludrocortisone much faster than normal. This makes the fludrocortisone less effective in your body.
Rifampin carries more major-labeled pairs than Fludrocortisone
SPL source-record counts only. This page's band is minor · classes on file: Fludrocortisone (Mineralocorticoid); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Fludrocortisone's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Fludrocortisone
- Furosemide
- Aspirin
- Amphotericin B
- Ethacrynic Acid
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.