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What the FDA labels say about taking them together

Amphotericin b and fludrocortisone

Fludrocortisone's FDA label of October 29, 2024 names amphotericin b in its drug interactions section; the amphotericin b label PlainMeds reads does not name fludrocortisone.

Check it at the source: the amphotericin b FDA label on DailyMed (effective June 3, 2025, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.); the fludrocortisone FDA label on DailyMed (effective October 29, 2024, Zydus Lifesciences Limited).

What does the amphotericin b label say about fludrocortisone?

Amphotericin b's label (effective June 3, 2025) does not name fludrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Amphotericin B), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective June 3, 2025 (SPL set 2b2f3ff5-9d62-4ad2-8eac-1181e5911513), via openFDA; the full label on DailyMed

What does the fludrocortisone label say about amphotericin b?

Fludrocortisone label, drug interactions

Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide)–enhanced hypokalemia.

Source: FDA drug label (Fludrocortisone acetate), Zydus Lifesciences Limited, effective October 29, 2024 (SPL set 6c4a7d2d-00a4-4d80-ab4c-2afd4e4f614e), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

5Amphotericin b generic labelers
15Fludrocortisone generic labelers
Amphotericin bFludrocortisone
Labeled forFungal infectionsn/a
Boxed warningNoNo
Pharmacy cost (NADAC)n/a$0.311 per tablet 0.1 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?