Fludrocortisone and Amphotericin B Interaction
Drug interaction information between Fludrocortisone and Amphotericin B.
Fludrocortisone and Amphotericin B have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fludrocortisone and Amphotericin B. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications can cause your body to lose potassium. Taking them together increases the risk of your potassium levels becoming dangerously low.
FDA Label Information
Amphotericin B or potassium-depleting diuretics (benzothiadiazines and related drugs, ethacrynic acid and furosemide) – enhanced hypokalemia.
Fludrocortisone Also Interacts With
- Furosemide minor
- Aspirin minor
- Rifampin minor
- Ethacrynic Acid minor
- Phenytoin minor
Amphotericin B Also Interacts With
- Cidofovir major
- Ganciclovir moderate
- Valganciclovir moderate
- Ketoconazole minor
- Anidulafungin minor
Frequently Asked Questions
What SPL severity band is on file for Fludrocortisone + Amphotericin B?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amphotericin B has 12 labeled pairs on file vs Fludrocortisone's 6. In the minor band specifically: Fludrocortisone has 6 (also Furosemide, Aspirin, Rifampin, Ethacrynic Acid); Amphotericin B has 9 (also Ketoconazole, Anidulafungin, Dexamethasone, Dronabinol).
What mechanism field is on file for Fludrocortisone and Amphotericin B?
Both of these medications can cause your body to lose potassium. Taking them together increases the risk of your potassium levels becoming dangerously low.
Amphotericin B carries more major-labeled pairs than Fludrocortisone
SPL source-record counts only. This page's band is minor · classes on file: Fludrocortisone (Mineralocorticoid); Amphotericin B (Polyene Antifungal).
Amphotericin B has 1 major-labeled pair vs Fludrocortisone's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Fludrocortisone
- Furosemide
- Aspirin
- Rifampin
- Ethacrynic Acid
1 major · 2 moderate · 9 minor · 12 total
- Other minor peers for Amphotericin B
- Ketoconazole
- Anidulafungin
- Dexamethasone
- Dronabinol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.