What the FDA labels say about taking them together
Aspirin and fludrocortisone
Fludrocortisone's FDA label of October 29, 2024 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name fludrocortisone. The fludrocortisone label: “Aspirin –increased ulcerogenic effect; decreased pharmacologic effect of aspirin.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the fludrocortisone FDA label on DailyMed (effective October 29, 2024, Zydus Lifesciences Limited).
What does the aspirin label say about fludrocortisone?
Aspirin's label (effective September 9, 2025) does not name fludrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the fludrocortisone label say about aspirin?
Fludrocortisone label, drug interactionsAspirin –increased ulcerogenic effect; decreased pharmacologic effect of aspirin.
Source: FDA drug label (Fludrocortisone acetate), Zydus Lifesciences Limited, effective October 29, 2024 (SPL set 6c4a7d2d-00a4-4d80-ab4c-2afd4e4f614e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Fludrocortisone | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.311 per tablet 0.1 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once