Fludrocortisone and Aspirin Interaction
Drug interaction information between Fludrocortisone and Aspirin.
Fludrocortisone and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fludrocortisone and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these together increases the risk of stomach ulcers and can make aspirin less effective. If you stop the steroid suddenly, aspirin levels in your blood could rise to unsafe levels.
FDA Label Information
Aspirin – increased ulcerogenic effect; decreased pharmacologic effect of aspirin. Rarely salicylate toxicity may occur in patients who discontinue steroids after concurrent high-dose aspirin therapy. Monitor salicylate levels or the therapeutic effect for which aspirin is given; adjust salicylate dosage accordingly if effect is altered (see PRECAUTIONS, General ).
Fludrocortisone Also Interacts With
- Furosemide minor
- Rifampin minor
- Amphotericin B minor
- Ethacrynic Acid minor
- Phenytoin minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Fludrocortisone + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Fludrocortisone's 6. In the minor band specifically: Fludrocortisone has 6 (also Furosemide, Rifampin, Amphotericin B, Ethacrynic Acid); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Fludrocortisone and Aspirin?
Taking these together increases the risk of stomach ulcers and can make aspirin less effective. If you stop the steroid suddenly, aspirin levels in your blood could rise to unsafe levels.
Aspirin carries more major-labeled pairs than Fludrocortisone
SPL source-record counts only. This page's band is minor · classes on file: Fludrocortisone (Mineralocorticoid); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Fludrocortisone's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 6 minor · 6 total
- Other minor peers for Fludrocortisone
- Furosemide
- Rifampin
- Amphotericin B
- Ethacrynic Acid
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.