Esomeprazole and Digoxin Interaction
Drug interaction information between Esomeprazole and Digoxin.
Esomeprazole and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Esomeprazole and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking esomeprazole can raise the levels of digoxin in your body. It likely changes how much of the drug is absorbed or handled by your system.
FDA Label Information
Conivaptan 33% 43% Diltiazem 20% NA Indomethacin 40% NA Mirabegron 29% 27% Nefazodone 27% 15% Nifedipine 45% NA Propantheline 24% 24% Quinine NA 33% Rabeprazole 29% 19% Saquinavir 27% 49% Spironolactone 25% NA Telmisartan 20 to 49% NA Tricagrelor 31% 28% Tolvaptan 30% 20% Trimethoprim 22 to 28% NA Digoxin concentrations increased, but magnitude is unclear Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole Measure serum digoxin concentrations before initiating concomitant drugs.
Esomeprazole Also Interacts With
- Posaconazole major
- Clopidogrel moderate
- Risedronate minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Esomeprazole + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Esomeprazole's 4. In the minor band specifically: Esomeprazole has 2 (also Risedronate); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Esomeprazole and Digoxin?
Taking esomeprazole can raise the levels of digoxin in your body. It likely changes how much of the drug is absorbed or handled by your system.
Digoxin carries more major-labeled pairs than Esomeprazole
SPL source-record counts only. This page's band is minor · classes on file: Esomeprazole (Proton Pump Inhibitor (PPI)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Esomeprazole's 1. This page itself is in the minor band, not the major band.
1 major · 1 moderate · 2 minor · 4 total
- Other minor peers for Esomeprazole
- Risedronate
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.