Esomeprazole and Posaconazole Interaction
Drug interaction information between Esomeprazole and Posaconazole.
Esomeprazole and Posaconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Esomeprazole and Posaconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Esomeprazole changes the acid levels in the stomach, which can prevent certain forms of posaconazole from being absorbed into the body. This may make the antifungal treatment less effective.
FDA Label Information
Interaction Drug Interaction Rifabutin, phenytoin, efavirenz, cimetidine, esomeprazole* Avoid coadministration unless the benefit outweighs the risks ( 7.6 , 7.7 , 7.8 , 7.9 ) Other drugs metabolized by CYP3A4 Consider dosage adjustment and monitor for adverse effects and toxicity ( 7.1 , 7.10 , 7.11 ) Digoxin Monitor digoxin plasma concentrations ( 7.12 ) Fosamprenavir, metoclopramide* Monitor for breakthrough fungal infections ( 7.6 , 7.13 ) *The drug interactions with esomeprazole and metoclopramide do not apply to posaconazole tablets.
Esomeprazole Also Interacts With
- Clopidogrel moderate
- Digoxin minor
- Risedronate minor
Posaconazole Also Interacts With
- Digoxin major
- Cimetidine major
- Metoclopramide major
- Phenytoin major
- Efavirenz/Emtricitabine/Tenofovir moderate
Frequently Asked Questions
What SPL severity band is on file for Esomeprazole + Posaconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Posaconazole has 27 labeled pairs on file vs Esomeprazole's 4. In the major band specifically: Esomeprazole has 1; Posaconazole has 5 (also Digoxin, Cimetidine, Metoclopramide, Phenytoin).
What mechanism field is on file for Esomeprazole and Posaconazole?
Esomeprazole changes the acid levels in the stomach, which can prevent certain forms of posaconazole from being absorbed into the body. This may make the antifungal treatment less effective.
Posaconazole carries more major-labeled pairs than Esomeprazole
SPL source-record counts only. This page's band is major · classes on file: Esomeprazole (Proton Pump Inhibitor (PPI)); Posaconazole (Azole Antifungal).
Posaconazole has 5 major-labeled pairs vs Esomeprazole's 1.
1 major · 1 moderate · 2 minor · 4 total
Esomeprazole has no other major-band peer in this dataset besides Posaconazole.
5 major · 5 moderate · 17 minor · 27 total
- Other major peers for Posaconazole
- Digoxin
- Cimetidine
- Metoclopramide
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.