digoxin vs esomeprazole
Side-by-side comparison of digoxin and esomeprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Conivaptan 33% 43% Diltiazem 20% NA Indomethacin 40% NA Mirabegron 29% 27% Nefazodone 27% 15% Nifedipine 45% NA Propantheline 24% 24% Quinine NA 33% Rabeprazole 29% 19% Saquinavir 27% 49% Spironolactone 25% NA Telmisartan 20 to 49% NA Tricagrelor 31% 28% Tolvaptan 30% 20% Trimethoprim 22 to 28% NA Digoxin concentrations increased, but magnitude is unclear Alprazolam, azithromycin, cyclosporine, diclofenac, diphenoxylate, epoprostenol, esomeprazole, ibuprofen, ketoconazole, lansoprazole, metformin, omeprazole Measure serum digoxin concentrations before initiating concomitant drugs.
Recommendation: Have your digoxin blood levels tested before starting esomeprazole. Your healthcare provider will decide if your dose needs to be changed to keep you safe.
Lanoxin
Nexium
Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.
Esomeprazole (Nexium) is a drug that reduces stomach acid. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.
This medicine treats frequent heartburn. Frequent heartburn means you have heartburn 2 or more days a week. This medicine is not for immediate relief of heartburn. It may take 1 to 4 days to work fully.
Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.
Esomeprazole works by reducing the amount of acid your stomach makes. It blocks the proton pump in your stomach lining. This pump is responsible for producing stomach acid.
- • Nausea
- • Vomiting
- • Diarrhea
- • Dizziness
- • Headache
- • Nausea
- • Diarrhea
- • Headache
- Shortness of breath 6,062
- Feeling sick to your stomach 4,747
- Feeling lightheaded or unsteady 4,442
- Feeling very tired 4,174
- Irregular heartbeat 3,972
- Long-term kidney disease 5,020
- Sudden kidney damage 4,563
- Feeling sick to your stomach 4,005
- Loose or watery stools 3,869
- Feeling very tired 3,528
Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.
Do not take this medicine for more than 14 days, or more often than every 4 months, unless your doctor tells you to.
It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. Also, tell your doctor if you are breastfeeding or plan to breastfeed.
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How to Read This digoxin vs esomeprazole Comparison
digoxin is classified in the Cardiac Glycoside drug class, while esomeprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,397 submissions while esomeprazole has 20,985. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking esomeprazole can raise the levels of digoxin in your body. it likely changes how much of the drug is absorbed or handled by your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between digoxin and esomeprazole - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.