Edoxaban and Carbamazepine Interaction
Drug interaction information between Edoxaban and Carbamazepine.
Edoxaban and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Edoxaban and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up how your body clears edoxaban, which can make the blood thinner less effective.
FDA Label Information
Concomitant use of carbamazepine with rivaroxaban, apixaban, dabigatran, and edoxaban (direct acting oral anticoagulants) is expected to result in decreased plasma concentration of these anticoagulants that may be insufficient to achieve the intended therapeutic effect. In general, coadministration of carbamazepine with rivaroxaban, apixaban, dabigatran, and edoxaban should be avoided.
Edoxaban Also Interacts With
- Rifampin moderate
- Norepinephrine moderate
- Aspirin minor
- Darunavir minor
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Edoxaban + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Edoxaban's 5. In the minor band specifically: Edoxaban has 3 (also Aspirin, Darunavir); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Edoxaban and Carbamazepine?
Carbamazepine speeds up how your body clears edoxaban, which can make the blood thinner less effective.
Carbamazepine carries more major-labeled pairs than Edoxaban
SPL source-record counts only. This page's band is minor · classes on file: Edoxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Edoxaban's 0. This page itself is in the minor band, not the major band.
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.