Edoxaban and Darunavir Interaction
Drug interaction information between Edoxaban and Darunavir.
Edoxaban and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Edoxaban and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir stops a specific protein from moving edoxaban out of the body, which can increase the amount of medicine in your blood.
FDA Label Information
dabigatran etexilate edoxaban ↑ dabigatran ↑ edoxaban Refer to the dabigatran etexilate or edoxaban prescribing information for recommendations regarding co-administration. The specific recommendations are based on indication, renal function, and effect of the co-administered P-gp inhibitors on the concentration of dabigatran or edoxaban. Clinical monitoring is recommended when a DOAC not affected by CYP3A4 but transported by P-gp, including dabigatran etexilate and edoxaban, is co-administered with darunavir /ritonavir.
Edoxaban Also Interacts With
- Rifampin moderate
- Norepinephrine moderate
- Aspirin minor
- Carbamazepine minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Edoxaban + Darunavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Edoxaban's 5. In the minor band specifically: Edoxaban has 3 (also Aspirin, Carbamazepine); Darunavir has 70 (also Amlodipine, Metoprolol, Sertraline, Rosuvastatin).
What mechanism field is on file for Edoxaban and Darunavir?
Darunavir stops a specific protein from moving edoxaban out of the body, which can increase the amount of medicine in your blood.
Darunavir carries more major-labeled pairs than Edoxaban
SPL source-record counts only. This page's band is minor · classes on file: Edoxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Edoxaban's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 3 minor · 5 total
- Other minor peers for Edoxaban
- Aspirin
- Carbamazepine
15 major · 16 moderate · 70 minor · 101 total
- Other minor peers for Darunavir
- Amlodipine
- Metoprolol
- Sertraline
- Rosuvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.