Edoxaban and Darunavir Interaction
Drug interaction information between Edoxaban and Darunavir.
Edoxaban and Darunavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Edoxaban and Darunavir. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Darunavir stops a specific protein from moving edoxaban out of the body, which can increase the amount of medicine in your blood.
What To Do
Your doctor should monitor you carefully and check your kidney health to ensure the dose is safe for you.
FDA Label Information
dabigatran etexilate edoxaban ↑ dabigatran ↑ edoxaban Refer to the dabigatran etexilate or edoxaban prescribing information for recommendations regarding co-administration. The specific recommendations are based on indication, renal function, and effect of the co-administered P-gp inhibitors on the concentration of dabigatran or edoxaban. Clinical monitoring is recommended when a DOAC not affected by CYP3A4 but transported by P-gp, including dabigatran etexilate and edoxaban, is co-administered with darunavir /ritonavir.
Edoxaban Also Interacts With
- Rifampin moderate
- Norepinephrine moderate
- Aspirin minor
- Carbamazepine minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
Can I take Edoxaban and Darunavir together?
This is a minor interaction. Your doctor should monitor you carefully and check your kidney health to ensure the dose is safe for you.
How serious is the interaction between Edoxaban and Darunavir?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Edoxaban and Darunavir interact?
Darunavir stops a specific protein from moving edoxaban out of the body, which can increase the amount of medicine in your blood.
Understanding the Edoxaban and Darunavir Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Edoxaban belongs to the Direct Oral Anticoagulant (Factor Xa Inhibitor) class and Darunavir belongs to the HIV Protease Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Darunavir stops a specific protein from moving edoxaban out of the body, which can increase the amount of medicine in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Edoxaban has 5 total documented interactions on file in this dataset, and Darunavir has 101. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you carefully and check your kidney health to ensure the dose is safe for you. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Edoxaban or Darunavir based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.