Edoxaban and Rifampin Interaction
Drug interaction information between Edoxaban and Rifampin.
Edoxaban and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Edoxaban and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to clear the blood thinner too quickly, which could make the medicine fail to prevent blood clots.
FDA Label Information
( 7.1 ) Rifampin: Avoid concomitant use ( 7.2 ) 7.1 Anticoagulants, Antiplatelets, Thrombolytics, and SSRIs/SNRIs Co-administration of anticoagulants, antiplatelet drugs, thrombolytics and SSRIs or SNRIs may increase the risk of bleeding. 7.2 P-gp Inducers Avoid the concomitant use of SAVAYSA with rifampin [see Clinical Pharmacology (12.3) ] .
Edoxaban Also Interacts With
- Norepinephrine moderate
- Aspirin minor
- Carbamazepine minor
- Darunavir minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Edoxaban + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Edoxaban's 5. In the moderate band specifically: Edoxaban has 2 (also Norepinephrine); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Edoxaban and Rifampin?
Rifampin causes your body to clear the blood thinner too quickly, which could make the medicine fail to prevent blood clots.
Rifampin carries more major-labeled pairs than Edoxaban
SPL source-record counts only. This page's band is moderate · classes on file: Edoxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Edoxaban's 0. This page itself is in the moderate band, not the major band.
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.