Edoxaban and Norepinephrine Interaction
Drug interaction information between Edoxaban and Norepinephrine.
Edoxaban and Norepinephrine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Edoxaban and Norepinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines together can increase your risk of serious bleeding.
FDA Label Information
7 DRUG INTERACTIONS Anticoagulants, Antiplatelets, Thrombolytics, and Selective Serotonin Reuptake Inhibitors (SSRIs)/Serotonin Norepinephrine Reuptake Inhibitors (SNRIs): Avoid concomitant use due to increased risk of bleeding.
Edoxaban Also Interacts With
- Rifampin moderate
- Aspirin minor
- Carbamazepine minor
- Darunavir minor
Norepinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Clopidogrel moderate
- Deutetrabenazine moderate
- Digoxin moderate
Frequently Asked Questions
What SPL severity band is on file for Edoxaban + Norepinephrine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Norepinephrine has 50 labeled pairs on file vs Edoxaban's 5. In the moderate band specifically: Edoxaban has 2 (also Rifampin); Norepinephrine has 7 (also Carbidopa/Levodopa, Clopidogrel, Deutetrabenazine, Digoxin).
What mechanism field is on file for Edoxaban and Norepinephrine?
Taking these medicines together can increase your risk of serious bleeding.
Norepinephrine carries more major-labeled pairs than Edoxaban
SPL source-record counts only. This page's band is moderate · classes on file: Edoxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Norepinephrine (Vasopressor (Alpha-1 Agonist)).
Norepinephrine has 1 major-labeled pair vs Edoxaban's 0. This page itself is in the moderate band, not the major band.
1 major · 7 moderate · 42 minor · 50 total
- Other moderate peers for Norepinephrine
- Carbidopa/Levodopa
- Clopidogrel
- Deutetrabenazine
- Digoxin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.