Dofetilide and Digoxin Interaction
Drug interaction information between Dofetilide and Digoxin.
Dofetilide and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dofetilide and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines at the same time increases the risk of a serious and potentially fatal irregular heart rhythm. Both drugs change how electricity moves through the heart.
FDA Label Information
Antiarrthymics Dofetilide Concomitant administration with digoxin was associated with a higher rate of torsades de pointes Sotalol Proarrhythmic events were more common in patients receiving sotalol and digoxin than on either alone; it is not clear whether this represents an interaction or is related to the presence of CHF, a known risk factor for proarrhythmia, in patients receiving digoxin.
Dofetilide Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Dolutegravir major
- Dolutegravir/Lamivudine major
- Itraconazole major
- Clarithromycin moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Ivabradine moderate
- Dopamine moderate
Frequently Asked Questions
What SPL severity band is on file for Dofetilide + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Dofetilide's 8. In the moderate band specifically: Dofetilide has 3 (also Clarithromycin, Lamotrigine); Digoxin has 13 (also Sotalol, Ivabradine, Dopamine, Epinephrine).
What mechanism field is on file for Dofetilide and Digoxin?
Taking these medicines at the same time increases the risk of a serious and potentially fatal irregular heart rhythm. Both drugs change how electricity moves through the heart.
Dofetilide carries more major-labeled pairs than Digoxin
SPL source-record counts only. This page's band is moderate · classes on file: Dofetilide (Class III Antiarrhythmic); Digoxin (Cardiac Glycoside).
Dofetilide has 4 major-labeled pairs vs Digoxin's 2. This page itself is in the moderate band, not the major band.
4 major · 3 moderate · 1 minor · 8 total
- Other moderate peers for Dofetilide
- Clarithromycin
- Lamotrigine
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Ivabradine
- Dopamine
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.