Dofetilide and Dolutegravir/Lamivudine Interaction
Drug interaction information between Dofetilide and Dolutegravir/Lamivudine.
Dofetilide and Dolutegravir/Lamivudine have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Dofetilide and Dolutegravir/Lamivudine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
One of the medicines in this combination blocks the pathways your kidneys use to get rid of dofetilide. This can lead to dangerously high levels of dofetilide in your system.
FDA Label Information
7.2 Potential for DOVATO to Affect Other Drugs Dolutegravir, a component of DOVATO, inhibits the renal organic cation transporters (OCT)2 and multidrug and toxin extrusion transporter (MATE)1; thus, it may increase plasma concentrations of drugs eliminated via OCT2 or MATE1 such as dofetilide, dalfampridine, and metformin [see Contraindications ( 4 ), Drug Interactions ( 7.4 ), Clinical Pharmacology ( 12.3 )]. Coadministered Drug Class: Drug Name Effect on Concentration Clinical Comment Antiarrhythmic: Dofetilide ↑Dofetilide Coadministration is contraindicated with DOVATO [see...
Dofetilide Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Dolutegravir major
- Itraconazole major
- Clarithromycin moderate
- Digoxin moderate
Dolutegravir/Lamivudine Also Interacts With
- Metformin moderate
- Oxcarbazepine moderate
- Phenytoin moderate
- Phenobarbital moderate
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Dofetilide + Dolutegravir/Lamivudine?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dolutegravir/Lamivudine has 9 labeled pairs on file vs Dofetilide's 8. In the major band specifically: Dofetilide has 4 (also Bictegravir, Dolutegravir, Itraconazole); Dolutegravir/Lamivudine has 1.
What mechanism field is on file for Dofetilide and Dolutegravir/Lamivudine?
One of the medicines in this combination blocks the pathways your kidneys use to get rid of dofetilide. This can lead to dangerously high levels of dofetilide in your system.
Dofetilide carries more major-labeled pairs than Dolutegravir/Lamivudine
SPL source-record counts only. This page's band is major · classes on file: Dofetilide (Class III Antiarrhythmic); Dolutegravir/Lamivudine (Integrase Inhibitor / NRTI Combination).
Dofetilide has 4 major-labeled pairs vs Dolutegravir/Lamivudine's 1.
4 major · 3 moderate · 1 minor · 8 total
- Other major peers for Dofetilide
- Bictegravir
- Dolutegravir
- Itraconazole
1 major · 4 moderate · 4 minor · 9 total
Dolutegravir/Lamivudine has no other major-band peer in this dataset besides Dofetilide.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.