Dofetilide and Itraconazole Interaction
Drug interaction information between Dofetilide and Itraconazole.
Dofetilide and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Dofetilide and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole interferes with the way your body breaks down dofetilide, potentially causing the heart medication to reach dangerous levels.
FDA Label Information
Antiarrhythmics Disopyramide Dofetilide Dronedarone Quinidine a Contraindicated during and 2 weeks after itraconazole treatment.
Dofetilide Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Dolutegravir major
- Dolutegravir/Lamivudine major
- Clarithromycin moderate
- Digoxin moderate
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Dofetilide + Itraconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Dofetilide's 8. In the major band specifically: Dofetilide has 4 (also Bictegravir, Dolutegravir, Dolutegravir/Lamivudine); Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone).
What mechanism field is on file for Dofetilide and Itraconazole?
Itraconazole interferes with the way your body breaks down dofetilide, potentially causing the heart medication to reach dangerous levels.
Itraconazole carries more major-labeled pairs than Dofetilide
SPL source-record counts only. This page's band is major · classes on file: Dofetilide (Class III Antiarrhythmic); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Dofetilide's 4.
4 major · 3 moderate · 1 minor · 8 total
- Other major peers for Dofetilide
- Bictegravir
- Dolutegravir
- Dolutegravir/Lamivudine
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.