Dofetilide and Clarithromycin Interaction
Drug interaction information between Dofetilide and Clarithromycin.
Dofetilide and Clarithromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dofetilide and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin affects how this heart medicine is broken down, which can increase the risk of a life-threatening irregular heartbeat.
FDA Label Information
Clinically Significant Drug Interactions with Clarithromycin Tablets Drugs That Are Affected By Clarithromycin Tablets Drug(s) with Pharmacokinetics Affected by Clarithromycin Tablets Recommendation Comments Antiarrhythmics: Disopyramide Quinidine Dofetilide Amiodarone Sotalol Procainamide Not Recommended Disopyramide, Quinidine: There have been postmarketing reports of torsades de pointes occurring with concurrent use of clarithromycin and quinidine or disopyramide.
Dofetilide Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir major
- Dolutegravir major
- Dolutegravir/Lamivudine major
- Itraconazole major
- Digoxin moderate
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Dofetilide + Clarithromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Dofetilide's 8. In the moderate band specifically: Dofetilide has 3 (also Digoxin, Lamotrigine); Clarithromycin has 35 (also Omeprazole, Methylprednisolone, Sildenafil, Valproate).
What mechanism field is on file for Dofetilide and Clarithromycin?
Clarithromycin affects how this heart medicine is broken down, which can increase the risk of a life-threatening irregular heartbeat.
Clarithromycin carries more major-labeled pairs than Dofetilide
SPL source-record counts only. This page's band is moderate · classes on file: Dofetilide (Class III Antiarrhythmic); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Dofetilide's 4. This page itself is in the moderate band, not the major band.
4 major · 3 moderate · 1 minor · 8 total
- Other moderate peers for Dofetilide
- Digoxin
- Lamotrigine
16 major · 35 moderate · 30 minor · 81 total
- Other moderate peers for Clarithromycin
- Omeprazole
- Methylprednisolone
- Sildenafil
- Valproate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.