Dofetilide · more major-labeled pairs than Bictegravir
SPL labels Dofetilide + Bictegravir as major; Dofetilide 4 / Bictegravir 2 in that band.
Mechanism on file: The HIV medicine blocks the way your body removes the heart medicine dofetilide, causing it to build up to dangerous levels. High levels of dofetilide can cause life-threatening heart rhythm problems.
FDA SPL severity: Major
Dofetilide + Bictegravir · SPL mechanism field
The HIV medicine blocks the way your body removes the heart medicine dofetilide, causing it to build up to dangerous levels. High levels of dofetilide can cause life-threatening heart rhythm problems.
Major band excerpt · Dofetilide with Bictegravir
Coadministration of BIKTARVY with drugs that are substrates of OCT2 and MATE1 (e.g., dofetilide) may increase their plasma concentrations (see Table 3 ). Clinical Comment Antiarrhythmics: dofetilide ↑ Dofetilide Coadministration is contraindicated due to the potential for serious and/or life-threatening events associated with dofetilide therapy [see Contraindications (4) ] .
Dofetilide · 4 major-labeled pairs (vs Bictegravir's 2)
- Dolutegravir major
- Dolutegravir/Lamivudine major
- Itraconazole major
- Clarithromycin moderate
Bictegravir · 19 SPL pairs (broader portfolio than Dofetilide)
- Rifampin major
- Acyclovir minor
- Carbamazepine minor
- Cidofovir minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.