Diclofenac and Indomethacin Interaction
Drug interaction information between Diclofenac and Indomethacin.
Diclofenac and Indomethacin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Diclofenac and Indomethacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These are both NSAID pain relievers that work the same way, and combining them increases the chance of stomach or kidney damage.
FDA Label Information
NSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Diclofenac Also Interacts With
- Misoprostol moderate
- Warfarin moderate
- Celecoxib minor
- Digoxin minor
- Fluconazole minor
Indomethacin Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Heparin moderate
- Perindopril moderate
- Warfarin moderate
Frequently Asked Questions
What SPL severity band is on file for Diclofenac + Indomethacin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Indomethacin has 35 labeled pairs on file vs Diclofenac's 11. In the minor band specifically: Diclofenac has 9 (also Celecoxib, Digoxin, Fluconazole, Mefenamic Acid); Indomethacin has 30 (also Meloxicam, Aspirin, Cyclosporine, Lithium).
What mechanism field is on file for Diclofenac and Indomethacin?
These are both NSAID pain relievers that work the same way, and combining them increases the chance of stomach or kidney damage.
Indomethacin's labeled portfolio outnumbers Diclofenac
SPL source-record counts only. This page's band is minor · classes on file: Diclofenac (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Indomethacin (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Diclofenac
- Celecoxib
- Digoxin
- Fluconazole
- Mefenamic Acid
0 major · 5 moderate · 30 minor · 35 total
- Other minor peers for Indomethacin
- Meloxicam
- Aspirin
- Cyclosporine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.