Dextromethorphan and Fluvoxamine Interaction
Drug interaction information between Dextromethorphan and Fluvoxamine.
Dextromethorphan and Fluvoxamine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dextromethorphan and Fluvoxamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine can interfere with how the body processes dextromethorphan. This makes the body act like a 'poor metabolizer,' which can lead to higher drug levels.
FDA Label Information
Such individuals have been referred to as “poor metabolizers” (PM) of drugs such as debrisoquin, dextromethorphan, and tricyclic antidepressants.
Dextromethorphan Also Interacts With
- Safinamide major
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Abiraterone minor
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Metoprolol minor
Frequently Asked Questions
What SPL severity band is on file for Dextromethorphan + Fluvoxamine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Dextromethorphan's 15. In the minor band specifically: Dextromethorphan has 11 (also Abiraterone, Aripiprazole, Brexpiprazole, Desvenlafaxine); Fluvoxamine has 36 (also Metoprolol, Omeprazole, Fluoxetine, Aspirin).
What mechanism field is on file for Dextromethorphan and Fluvoxamine?
Fluvoxamine can interfere with how the body processes dextromethorphan. This makes the body act like a 'poor metabolizer,' which can lead to higher drug levels.
Fluvoxamine's labeled portfolio outnumbers Dextromethorphan
SPL source-record counts only. This page's band is minor · classes on file: Dextromethorphan (Antitussive); Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)).
1 major · 3 moderate · 11 minor · 15 total
- Other minor peers for Dextromethorphan
- Abiraterone
- Aripiprazole
- Brexpiprazole
- Desvenlafaxine
1 major · 3 moderate · 36 minor · 40 total
- Other minor peers for Fluvoxamine
- Metoprolol
- Omeprazole
- Fluoxetine
- Aspirin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.