Fluvoxamine and Metoprolol Interaction
Drug interaction information between Fluvoxamine and Metoprolol.
Fluvoxamine and Metoprolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluvoxamine and Metoprolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine slows down how your body processes metoprolol. This can cause the heart medicine to build up, leading to a dangerously slow heart rate or low blood pressure.
FDA Label Information
Propranolol or Metoprolol: Reduce dose if coadministered with fluvoxamine and titrate more cautiously ( 7.3 ) . One case of bradycardia and hypotension and a second case of orthostatic hypotension have been reported with the coadministration of immediate-release fluvoxamine maleate tablets and metoprolol. If propranolol or metoprolol is coadministered with fluvoxamine maleate extended-release capsules, a reduction in the initial beta-blocker dose and more cautious dose titration are recommended.
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Omeprazole minor
Metoprolol Also Interacts With
- Theophylline major
- Clonidine moderate
- Diltiazem moderate
- Verapamil moderate
- Fluoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Fluvoxamine + Metoprolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Metoprolol's 18. In the minor band specifically: Fluvoxamine has 36 (also Omeprazole, Fluoxetine, Aspirin, Propranolol); Metoprolol has 14 (also Fluoxetine, Paroxetine, Propafenone, Epinephrine).
What mechanism field is on file for Fluvoxamine and Metoprolol?
Fluvoxamine slows down how your body processes metoprolol. This can cause the heart medicine to build up, leading to a dangerously slow heart rate or low blood pressure.
Fluvoxamine's labeled portfolio outnumbers Metoprolol
SPL source-record counts only. This page's band is minor · classes on file: Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)); Metoprolol (Beta-Blocker).
1 major · 3 moderate · 36 minor · 40 total
- Other minor peers for Fluvoxamine
- Omeprazole
- Fluoxetine
- Aspirin
- Propranolol
1 major · 3 moderate · 14 minor · 18 total
- Other minor peers for Metoprolol
- Fluoxetine
- Paroxetine
- Propafenone
- Epinephrine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.