Dextromethorphan and Brexpiprazole Interaction
Drug interaction information between Dextromethorphan and Brexpiprazole.
Dextromethorphan and Brexpiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dextromethorphan and Brexpiprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Brexpiprazole does not interfere with the liver enzymes that your body uses to break down dextromethorphan.
FDA Label Information
Additionally, no dosage adjustment for substrates of CYP2D6 (e.g., dextromethorphan), CYP3A4 (e.g., lovastatin), CYP2B6 (e.g., bupropion), BCRP (e.g., rosuvastatin), or P-gp (e.g., fexofenadine) is required when administered concomitantly with REXULTI.
Dextromethorphan Also Interacts With
- Safinamide major
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Abiraterone minor
Brexpiprazole Also Interacts With
- Omeprazole minor
- Rosuvastatin minor
- Bupropion minor
- Fluoxetine minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Dextromethorphan + Brexpiprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dextromethorphan has 15 labeled pairs on file vs Brexpiprazole's 9. In the minor band specifically: Dextromethorphan has 11 (also Abiraterone, Aripiprazole, Desvenlafaxine, Fluvoxamine); Brexpiprazole has 9 (also Omeprazole, Rosuvastatin, Bupropion, Fluoxetine).
What mechanism field is on file for Dextromethorphan and Brexpiprazole?
Brexpiprazole does not interfere with the liver enzymes that your body uses to break down dextromethorphan.
Dextromethorphan carries more major-labeled pairs than Brexpiprazole
SPL source-record counts only. This page's band is minor · classes on file: Dextromethorphan (Antitussive); Brexpiprazole (Atypical Antipsychotic).
Dextromethorphan has 1 major-labeled pair vs Brexpiprazole's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 11 minor · 15 total
- Other minor peers for Dextromethorphan
- Abiraterone
- Aripiprazole
- Desvenlafaxine
- Fluvoxamine
0 major · 0 moderate · 9 minor · 9 total
- Other minor peers for Brexpiprazole
- Omeprazole
- Rosuvastatin
- Bupropion
- Fluoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.