Dextromethorphan and Rasagiline Interaction
Drug interaction information between Dextromethorphan and Rasagiline.
Dextromethorphan and Rasagiline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dextromethorphan and Rasagiline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs at the same time can cause severe changes in your brain chemistry. This can lead to unusual behavior, confusion, or a loss of touch with reality.
FDA Label Information
7 DRUG INTERACTIONS Meperidine: Risk of serotonin syndrome (4, 7.1) Dextromethorphan: Risk of psychosis or bizarre behavior (4, 7.2) MAO inhibitors: Risk of non-selective MAO inhibition and hypertensive crisis (4, 7.3) 7.1 Meperidine Serious, sometimes fatal reactions have been precipitated with concomitant use of meperidine (e.g., Demerol and other tradenames) and MAO inhibitors including selective MAO-B inhibitors [see Contraindications (4)] . 7.2 Dextromethorphan The concomitant use of rasagiline tablets and dextromethorphan was not allowed in clinical studies. The combination of MAO...
Dextromethorphan Also Interacts With
- Safinamide major
- Memantine moderate
- Tranylcypromine moderate
- Abiraterone minor
- Aripiprazole minor
Rasagiline Also Interacts With
- Meperidine moderate
- Tranylcypromine moderate
- Ciprofloxacin minor
- Dopamine minor
- Norepinephrine minor
Frequently Asked Questions
What SPL severity band is on file for Dextromethorphan + Rasagiline?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dextromethorphan has 15 labeled pairs on file vs Rasagiline's 7. In the moderate band specifically: Dextromethorphan has 3 (also Memantine, Tranylcypromine); Rasagiline has 3 (also Meperidine, Tranylcypromine).
What mechanism field is on file for Dextromethorphan and Rasagiline?
Taking these drugs at the same time can cause severe changes in your brain chemistry. This can lead to unusual behavior, confusion, or a loss of touch with reality.
Dextromethorphan carries more major-labeled pairs than Rasagiline
SPL source-record counts only. This page's band is moderate · classes on file: Dextromethorphan (Antitussive); Rasagiline (MAO-B Inhibitor).
Dextromethorphan has 1 major-labeled pair vs Rasagiline's 0. This page itself is in the moderate band, not the major band.
1 major · 3 moderate · 11 minor · 15 total
- Other moderate peers for Dextromethorphan
- Memantine
- Tranylcypromine
0 major · 3 moderate · 4 minor · 7 total
- Other moderate peers for Rasagiline
- Meperidine
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.