Dextromethorphan and Desvenlafaxine Interaction
Drug interaction information between Dextromethorphan and Desvenlafaxine.
Dextromethorphan and Desvenlafaxine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dextromethorphan and Desvenlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Desvenlafaxine does not significantly affect the liver enzymes that process dextromethorphan.
FDA Label Information
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Dextromethorphan Also Interacts With
- Safinamide major
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Abiraterone minor
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Dextromethorphan + Desvenlafaxine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desvenlafaxine has 19 labeled pairs on file vs Dextromethorphan's 15. In the minor band specifically: Dextromethorphan has 11 (also Abiraterone, Aripiprazole, Brexpiprazole, Fluvoxamine); Desvenlafaxine has 13 (also Metoprolol, Buspirone, Aripiprazole, Atomoxetine).
What mechanism field is on file for Dextromethorphan and Desvenlafaxine?
Desvenlafaxine does not significantly affect the liver enzymes that process dextromethorphan.
Dextromethorphan carries more major-labeled pairs than Desvenlafaxine
SPL source-record counts only. This page's band is minor · classes on file: Dextromethorphan (Antitussive); Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Dextromethorphan has 1 major-labeled pair vs Desvenlafaxine's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 11 minor · 15 total
- Other minor peers for Dextromethorphan
- Abiraterone
- Aripiprazole
- Brexpiprazole
- Fluvoxamine
0 major · 6 moderate · 13 minor · 19 total
- Other minor peers for Desvenlafaxine
- Metoprolol
- Buspirone
- Aripiprazole
- Atomoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.