Dextromethorphan and Safinamide Interaction
Drug interaction information between Dextromethorphan and Safinamide.
Dextromethorphan and Safinamide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Dextromethorphan and Safinamide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Safinamide is an MAO inhibitor, and taking it with dextromethorphan can cause serious mental side effects like psychosis or strange behavior.
FDA Label Information
7.4 Dextromethorphan The combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or bizarre behavior. Therefore, in view of XADAGO's MAO inhibitory activity, dextromethorphan is contraindicated for use with XADAGO.
Dextromethorphan Also Interacts With
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Abiraterone minor
- Aripiprazole minor
Safinamide Also Interacts With
- Tramadol major
- Methylphenidate major
- Linezolid major
- Methadone major
- Meperidine major
Frequently Asked Questions
What SPL severity band is on file for Dextromethorphan + Safinamide?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dextromethorphan has 15 labeled pairs on file vs Safinamide's 10. In the major band specifically: Dextromethorphan has 1; Safinamide has 6 (also Tramadol, Methylphenidate, Linezolid, Methadone).
What mechanism field is on file for Dextromethorphan and Safinamide?
Safinamide is an MAO inhibitor, and taking it with dextromethorphan can cause serious mental side effects like psychosis or strange behavior.
Safinamide carries more major-labeled pairs than Dextromethorphan
SPL source-record counts only. This page's band is major · classes on file: Dextromethorphan (Antitussive); Safinamide (MAO-B Inhibitor).
Safinamide has 6 major-labeled pairs vs Dextromethorphan's 1.
1 major · 3 moderate · 11 minor · 15 total
Dextromethorphan has no other major-band peer in this dataset besides Safinamide.
6 major · 0 moderate · 4 minor · 10 total
- Other major peers for Safinamide
- Tramadol
- Methylphenidate
- Linezolid
- Methadone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.