Fluvoxamine and Omeprazole Interaction
Drug interaction information between Fluvoxamine and Omeprazole.
Fluvoxamine and Omeprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluvoxamine and Omeprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine blocks the liver enzymes that are responsible for breaking down omeprazole. This can cause omeprazole levels to stay in your system longer than they should.
FDA Label Information
Based on a finding of substantial interactions of fluvoxamine with certain of these drugs (see later parts of this section and also WARNINGS AND PRECAUTIONS [ 5 ] for details) and limited in vitro data for CYP3A4, it appears that fluvoxamine inhibits several cytochrome P450 isoenzymes that are known to be involved in the metabolism of other drugs such as: CYP1A2 (e.g., warfarin, theophylline, propranolol, tizanidine), CYP2C9 (e.g., warfarin), CYP3A4 (e.g., alprazolam), and CYP2C19 (e.g., omeprazole). A clinically significant fluvoxamine interaction is possible with drugs having a narrow...
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Metoprolol minor
Omeprazole Also Interacts With
- Theophylline major
- Clarithromycin moderate
- Clopidogrel moderate
- Darunavir moderate
- Tacrolimus Topical moderate
Frequently Asked Questions
What SPL severity band is on file for Fluvoxamine + Omeprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluvoxamine has 40 labeled pairs on file vs Omeprazole's 27. In the minor band specifically: Fluvoxamine has 36 (also Metoprolol, Fluoxetine, Aspirin, Propranolol); Omeprazole has 22 (also Aripiprazole, Atomoxetine, Brexpiprazole, Carbamazepine).
What mechanism field is on file for Fluvoxamine and Omeprazole?
Fluvoxamine blocks the liver enzymes that are responsible for breaking down omeprazole. This can cause omeprazole levels to stay in your system longer than they should.
Fluvoxamine's labeled portfolio outnumbers Omeprazole
SPL source-record counts only. This page's band is minor · classes on file: Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)); Omeprazole (Proton Pump Inhibitor (PPI)).
1 major · 3 moderate · 36 minor · 40 total
- Other minor peers for Fluvoxamine
- Metoprolol
- Fluoxetine
- Aspirin
- Propranolol
1 major · 4 moderate · 22 minor · 27 total
- Other minor peers for Omeprazole
- Aripiprazole
- Atomoxetine
- Brexpiprazole
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.