Fluvoxamine and Fluoxetine Interaction
Drug interaction information between Fluvoxamine and Fluoxetine.
Fluvoxamine and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluvoxamine and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs increase a chemical in the brain called serotonin. Taking them together can cause serotonin levels to become too high, which can lead to serious health problems.
FDA Label Information
If concomitant treatment with sumatriptan and an SSRI (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) is clinically warranted, appropriate observation of the patient is advised.
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Metoprolol minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Fluvoxamine + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Fluvoxamine's 40. In the minor band specifically: Fluvoxamine has 36 (also Metoprolol, Omeprazole, Aspirin, Propranolol); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Fluvoxamine and Fluoxetine?
Both of these drugs increase a chemical in the brain called serotonin. Taking them together can cause serotonin levels to become too high, which can lead to serious health problems.
Fluoxetine carries more major-labeled pairs than Fluvoxamine
SPL source-record counts only. This page's band is minor · classes on file: Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Fluvoxamine's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 36 minor · 40 total
- Other minor peers for Fluvoxamine
- Metoprolol
- Omeprazole
- Aspirin
- Propranolol
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.