Dextromethorphan and Aripiprazole Interaction
Drug interaction information between Dextromethorphan and Aripiprazole.
Dextromethorphan and Aripiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dextromethorphan and Aripiprazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Aripiprazole does not interfere with the way your body breaks down dextromethorphan.
What To Do
You can take these medications together without needing to change your dosage.
FDA Label Information
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.
Dextromethorphan Also Interacts With
- Safinamide major
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Abiraterone minor
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
Frequently Asked Questions
Can I take Dextromethorphan and Aripiprazole together?
This is a minor interaction. You can take these medications together without needing to change your dosage.
How serious is the interaction between Dextromethorphan and Aripiprazole?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Dextromethorphan and Aripiprazole interact?
Aripiprazole does not interfere with the way your body breaks down dextromethorphan.
Understanding the Dextromethorphan and Aripiprazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Dextromethorphan belongs to the Antitussive class and Aripiprazole belongs to the Atypical Antipsychotic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Aripiprazole does not interfere with the way your body breaks down dextromethorphan. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Dextromethorphan has 15 total documented interactions on file in this dataset, and Aripiprazole has 19. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can take these medications together without needing to change your dosage. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Dextromethorphan or Aripiprazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.