Dextromethorphan and Aripiprazole Interaction
Drug interaction information between Dextromethorphan and Aripiprazole.
Dextromethorphan and Aripiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dextromethorphan and Aripiprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Aripiprazole does not interfere with the way your body breaks down dextromethorphan.
FDA Label Information
In addition, no dosage adjustment is necessary for substrates of CYP2D6 (e.g., dextromethorphan, fluoxetine, paroxetine, or venlafaxine), CYP2C9 (e.g., warfarin), CYP2C19 (e.g., omeprazole, warfarin, escitalopram), or CYP3A4 (e.g., dextromethorphan) when co-administered with aripiprazole.
Dextromethorphan Also Interacts With
- Safinamide major
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Abiraterone minor
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
Frequently Asked Questions
What SPL severity band is on file for Dextromethorphan + Aripiprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aripiprazole has 19 labeled pairs on file vs Dextromethorphan's 15. In the minor band specifically: Dextromethorphan has 11 (also Abiraterone, Brexpiprazole, Desvenlafaxine, Fluvoxamine); Aripiprazole has 19 (also Omeprazole, Sertraline, Escitalopram, Fluoxetine).
What mechanism field is on file for Dextromethorphan and Aripiprazole?
Aripiprazole does not interfere with the way your body breaks down dextromethorphan.
Dextromethorphan carries more major-labeled pairs than Aripiprazole
SPL source-record counts only. This page's band is minor · classes on file: Dextromethorphan (Antitussive); Aripiprazole (Atypical Antipsychotic).
Dextromethorphan has 1 major-labeled pair vs Aripiprazole's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 11 minor · 15 total
- Other minor peers for Dextromethorphan
- Abiraterone
- Brexpiprazole
- Desvenlafaxine
- Fluvoxamine
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Sertraline
- Escitalopram
- Fluoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.