Desvenlafaxine and Aripiprazole Interaction
Drug interaction information between Desvenlafaxine and Aripiprazole.
Desvenlafaxine and Aripiprazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desvenlafaxine and Aripiprazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Desvenlafaxine does not change how the body processes aripiprazole through the liver.
FDA Label Information
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Aripiprazole Also Interacts With
- Omeprazole minor
- Sertraline minor
- Escitalopram minor
- Fluoxetine minor
- Famotidine minor
Frequently Asked Questions
What SPL severity band is on file for Desvenlafaxine + Aripiprazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Desvenlafaxine and Aripiprazole tie at 19 labeled pairs each. minor-band counts: Desvenlafaxine 13 alongside Metoprolol, Buspirone, Atomoxetine, Lithium; Aripiprazole 19 alongside Omeprazole, Sertraline, Escitalopram, Fluoxetine.
What mechanism field is on file for Desvenlafaxine and Aripiprazole?
Desvenlafaxine does not change how the body processes aripiprazole through the liver.
Desvenlafaxine and Aripiprazole · minor-band peers
SPL source-record counts only. This page's band is minor · classes on file: Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Aripiprazole (Atypical Antipsychotic).
0 major · 6 moderate · 13 minor · 19 total
- Other minor peers for Desvenlafaxine
- Metoprolol
- Buspirone
- Atomoxetine
- Lithium
0 major · 0 moderate · 19 minor · 19 total
- Other minor peers for Aripiprazole
- Omeprazole
- Sertraline
- Escitalopram
- Fluoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.