Desvenlafaxine and Selegiline Interaction
Drug interaction information between Desvenlafaxine and Selegiline.
Desvenlafaxine and Selegiline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Desvenlafaxine and Selegiline. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These medications both raise serotonin levels in your body. Combining them can lead to too much serotonin, which can cause a dangerous reaction.
What To Do
Avoid using these drugs at the same time. Talk to your doctor about a safe schedule for switching between these medications.
FDA Label Information
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of PRISTIQ with other serotonergic drugs increases the risk of serotonin syndrome.
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Warfarin moderate
Selegiline Also Interacts With
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Trazodone moderate
- Vortioxetine moderate
Frequently Asked Questions
Can I take Desvenlafaxine and Selegiline together?
This is a moderate interaction. Avoid using these drugs at the same time. Talk to your doctor about a safe schedule for switching between these medications.
How serious is the interaction between Desvenlafaxine and Selegiline?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Desvenlafaxine and Selegiline interact?
These medications both raise serotonin levels in your body. Combining them can lead to too much serotonin, which can cause a dangerous reaction.
Understanding the Desvenlafaxine and Selegiline Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Desvenlafaxine belongs to the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) class and Selegiline belongs to the Selective MAO-B Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These medications both raise serotonin levels in your body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Desvenlafaxine has 19 total documented interactions on file in this dataset, and Selegiline has 9. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid using these drugs at the same time. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Desvenlafaxine or Selegiline based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.