What the FDA labels say about taking them together
Desvenlafaxine and selegiline
Desvenlafaxine's FDA label (Pristiq Extended-Release) of April 28, 2026 names selegiline in its drug interactions section; selegiline's label does not name desvenlafaxine itself but warns about its class (SNRIs (serotonin and norepinephrine reuptake inhibitors)).
Check it at the source: the desvenlafaxine FDA label on DailyMed (effective January 27, 2023, Alembic Pharmaceuticals Limited); the selegiline FDA label on DailyMed (effective August 7, 2024, Rising Pharma Holdings, Inc.).
What does the desvenlafaxine label say about selegiline?
Pristiq Extended-Release label (Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., April 28, 2026), drug interactionsExamples; selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue
Source: FDA drug label (Pristiq Extended-Release, NDA021992), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective April 28, 2026 (SPL set 0f43610c-f290-46ea-d186-4f998ed99fce), via openFDA
Source: FDA drug label (Desvenlafaxine), Alembic Pharmaceuticals Limited, effective January 27, 2023 (SPL set 9f74708c-6f6a-46cf-8c79-87a25c2bb6f8), via openFDA; the full label on DailyMed
What does the selegiline label say about desvenlafaxine?
Selegiline's label does not name desvenlafaxine itself; it warns about its class (SNRIs (serotonin and norepinephrine reuptake inhibitors)):
Selegiline label, contraindicationsEMSAM (selegiline transdermal system) is contraindicated with selective serotonin reuptake inhibitors (SSRIs, e.g., fluoxetine, sertraline, and paroxetine); serotonin and norepinephrine reuptake inhibitors (SNRIs, e.g., venlafaxine and duloxetine); the tricyclic antidepressants clomipramine and imipramine, the opiate analgesics meperidine, tramadol, methadone, pentazocine, and propoxyphene; …
Selegiline label, contraindicationsSerotonergic drugs: selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), clomipramine and imipramine, meperidine, tramadol, methadone, pentazocine, and propoxyphene; and the antitussive agent dextromethorphan should not be used with EMSAM because of a risk of serotonin syndrome ( 4 , 5.2 ).
Source: FDA drug label (Selegiline Hydrochloride), Rising Pharma Holdings, Inc., effective August 7, 2024 (SPL set 23c4481f-d150-40c6-addb-b3e454ca914f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Desvenlafaxine | Selegiline | |
|---|---|---|
| Labeled for | Depression | Parkinson's disease, Depression |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.396 per unit 50 mg | $0.756 per capsule 5 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once