Desvenlafaxine and Atomoxetine Interaction
Drug interaction information between Desvenlafaxine and Atomoxetine.
Desvenlafaxine and Atomoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Desvenlafaxine and Atomoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Desvenlafaxine does not have a significant impact on the levels of atomoxetine in your body.
FDA Label Information
Examples desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine 7.2 Drugs Having No Clinically Important Interactions with PRISTIQ Based on pharmacokinetic studies, no dosage adjustment is required for drugs that are mainly metabolized by CYP3A4 (e.g., midazolam), or for drugs that are metabolized by both CYP2D6 and CYP3A4 (e.g., tamoxifen, aripiprazole), when administered concomitantly with PRISTIQ [see Clinical Pharmacology (12.3) ].
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Atomoxetine Also Interacts With
- Albuterol moderate
- Omeprazole minor
- Fluoxetine minor
- Methylphenidate minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Desvenlafaxine + Atomoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Desvenlafaxine has 19 labeled pairs on file vs Atomoxetine's 15. In the minor band specifically: Desvenlafaxine has 13 (also Metoprolol, Buspirone, Aripiprazole, Lithium); Atomoxetine has 14 (also Omeprazole, Fluoxetine, Methylphenidate, Warfarin).
What mechanism field is on file for Desvenlafaxine and Atomoxetine?
Desvenlafaxine does not have a significant impact on the levels of atomoxetine in your body.
Desvenlafaxine's labeled portfolio outnumbers Atomoxetine
SPL source-record counts only. This page's band is minor · classes on file: Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Atomoxetine (Selective Norepinephrine Reuptake Inhibitor).
0 major · 6 moderate · 13 minor · 19 total
- Other minor peers for Desvenlafaxine
- Metoprolol
- Buspirone
- Aripiprazole
- Lithium
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Atomoxetine
- Omeprazole
- Fluoxetine
- Methylphenidate
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.