What the FDA labels say about taking them together
Aspirin and desvenlafaxine
Desvenlafaxine's FDA label of January 27, 2023 names aspirin in its drug interactions section; the aspirin label PlainMeds reads does not name desvenlafaxine. The desvenlafaxine label: “These studies have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the desvenlafaxine FDA label on DailyMed (effective January 27, 2023, Alembic Pharmaceuticals Limited).
What does the aspirin label say about desvenlafaxine?
Aspirin's label (effective September 9, 2025) does not name desvenlafaxine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the desvenlafaxine label say about aspirin?
Desvenlafaxine label, drug interactionsThese studies have also shown that concurrent use of an NSAID or aspirin may potentiate this risk of bleeding.
Desvenlafaxine label, warnings and precautionsCaution patients about risk of bleeding associated with concomitant use of desvenlafaxine and NSAIDs, aspirin, or other drugs that affect coagulation (5.4).
Pristiq Extended-Release label (Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., April 28, 2026), drug interactionsExamples; NSAIDs, aspirin, and warfarin
Pristiq Extended-Release label (Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., April 28, 2026), warnings and precautionsIncreased Risk of Bleeding: Concomitant use of aspirin, NSAIDs, other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk ( 5.4 ).
Source: FDA drug label (Pristiq Extended-Release, NDA021992), Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective April 28, 2026 (SPL set 0f43610c-f290-46ea-d186-4f998ed99fce), via openFDA
Source: FDA drug label (Desvenlafaxine), Alembic Pharmaceuticals Limited, effective January 27, 2023 (SPL set 9f74708c-6f6a-46cf-8c79-87a25c2bb6f8), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Desvenlafaxine | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $0.396 per unit 50 mg |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once