Desvenlafaxine and Linezolid Interaction
Drug interaction information between Desvenlafaxine and Linezolid.
Desvenlafaxine and Linezolid have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Desvenlafaxine and Linezolid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs increase the levels of a brain chemical called serotonin. If serotonin levels get too high, it can cause a serious and potentially life-threatening reaction called serotonin syndrome.
FDA Label Information
• In a patient who is being treated with linezolid or intravenous methylene blue. Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of PRISTIQ with other serotonergic drugs increases the risk of serotonin syndrome.
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Warfarin moderate
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Frequently Asked Questions
What SPL severity band is on file for Desvenlafaxine + Linezolid?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Linezolid has 29 labeled pairs on file vs Desvenlafaxine's 19. In the moderate band specifically: Desvenlafaxine has 6 (also Aspirin, Phenelzine, Tranylcypromine, Selegiline); Linezolid has 3 (also Levomilnacipran, Vortioxetine).
What mechanism field is on file for Desvenlafaxine and Linezolid?
Both of these drugs increase the levels of a brain chemical called serotonin. If serotonin levels get too high, it can cause a serious and potentially life-threatening reaction called serotonin syndrome.
Linezolid carries more major-labeled pairs than Desvenlafaxine
SPL source-record counts only. This page's band is moderate · classes on file: Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Linezolid (Oxazolidinone Antibiotic).
Linezolid has 8 major-labeled pairs vs Desvenlafaxine's 0. This page itself is in the moderate band, not the major band.
0 major · 6 moderate · 13 minor · 19 total
- Other moderate peers for Desvenlafaxine
- Aspirin
- Phenelzine
- Tranylcypromine
- Selegiline
8 major · 3 moderate · 18 minor · 29 total
- Other moderate peers for Linezolid
- Levomilnacipran
- Vortioxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.