Darifenacin and Estradiol Interaction
Drug interaction information between Darifenacin and Estradiol.
Darifenacin and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darifenacin and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darifenacin does not interfere with how the body processes birth control hormones. It will not change the level of estradiol in your blood.
FDA Label Information
7.5 Combination oral contraceptives Darifenacin (10 mg three times daily) had no effect on the pharmacokinetics of the combination oral contraceptives containing levonorgestrel and ethinyl estradiol [see Clinical Pharmacology (12.3) ] .
Darifenacin Also Interacts With
- Thioridazine moderate
- Flecainide moderate
- Itraconazole moderate
- Fluoxetine minor
- Duloxetine minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Darifenacin + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Darifenacin's 18. In the minor band specifically: Darifenacin has 15 (also Fluoxetine, Duloxetine, Paroxetine, Diltiazem); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Darifenacin and Estradiol?
Darifenacin does not interfere with how the body processes birth control hormones. It will not change the level of estradiol in your blood.
Estradiol carries more major-labeled pairs than Darifenacin
SPL source-record counts only. This page's band is minor · classes on file: Darifenacin (Anticholinergic (Overactive Bladder)); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Darifenacin's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Darifenacin
- Fluoxetine
- Duloxetine
- Paroxetine
- Diltiazem
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.