Darifenacin and Duloxetine Interaction
Drug interaction information between Darifenacin and Duloxetine.
Darifenacin and Duloxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darifenacin and Duloxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Duloxetine blocks a specific liver protein that helps clear darifenacin from the body. This can lead to slightly higher levels of darifenacin.
FDA Label Information
7.2 CYP2D6 Inhibitors No dosing adjustments are recommended in the presence of CYP2D6 inhibitors (for example, paroxetine, fluoxetine, quinidine and duloxetine) [see Clinical Pharmacology (12.3) ] .
Darifenacin Also Interacts With
- Thioridazine moderate
- Flecainide moderate
- Itraconazole moderate
- Fluoxetine minor
- Estradiol minor
Duloxetine Also Interacts With
- Aspirin moderate
- Fluoxetine minor
- Famotidine minor
- Buspirone minor
- Paroxetine minor
Frequently Asked Questions
What SPL severity band is on file for Darifenacin + Duloxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Darifenacin and Duloxetine tie at 18 labeled pairs each. minor-band counts: Darifenacin 15 alongside Fluoxetine, Estradiol, Paroxetine, Diltiazem; Duloxetine 17 alongside Fluoxetine, Famotidine, Buspirone, Paroxetine.
What mechanism field is on file for Darifenacin and Duloxetine?
Duloxetine blocks a specific liver protein that helps clear darifenacin from the body. This can lead to slightly higher levels of darifenacin.
Darifenacin and Duloxetine · minor-band peers
SPL source-record counts only. This page's band is minor · classes on file: Darifenacin (Anticholinergic (Overactive Bladder)); Duloxetine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Darifenacin
- Fluoxetine
- Estradiol
- Paroxetine
- Diltiazem
0 major · 1 moderate · 17 minor · 18 total
- Other minor peers for Duloxetine
- Fluoxetine
- Famotidine
- Buspirone
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.