What the FDA labels say about taking them together
Darifenacin and duloxetine
Darifenacin's FDA label of February 10, 2026 names duloxetine in its drug interactions section; the duloxetine labels PlainMeds reads (2) do not name darifenacin. The darifenacin label: “No dosing adjustments are recommended in the presence of CYP2D6 inhibitors.”
Check it at the source: the darifenacin FDA label on DailyMed (effective February 10, 2026, Torrent Pharmaceuticals Limited); the duloxetine FDA label on DailyMed (effective May 14, 2024, SUN PHARMACEUTICAL INDUSTRIES, INC.).
What does the darifenacin label say about duloxetine?
Darifenacin label, drug interactionsNo dosing adjustments are recommended in the presence of CYP2D6 inhibitors (for example, paroxetine, fluoxetine, quinidine and duloxetine) [see Clinical Pharmacology (12.3)].
Source: FDA drug label (Darifenacin), Torrent Pharmaceuticals Limited, effective February 10, 2026 (SPL set e84f1ae3-b9a2-4a15-a299-c75373891cc1), via openFDA; the full label on DailyMed
What does the duloxetine label say about darifenacin?
Duloxetine's label (effective May 14, 2024) and its 1 other brand-application label do not name darifenacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (DRIZALMA SPRINKLE), SUN PHARMACEUTICAL INDUSTRIES, INC., effective May 14, 2024 (SPL set b41423b8-dfec-4d79-ba3c-e43a87803d85), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darifenacin | Duloxetine | |
|---|---|---|
| Labeled for | Overactive bladder | Depression, Anxiety, Nerve pain and fibromyalgia, Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.432 per tablet 15 mg tablet | $0.102 per capsule 30 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once