What the FDA labels say about taking them together
Darifenacin and paroxetine
Darifenacin's FDA label of February 10, 2026 names paroxetine in its drug interactions section; the paroxetine labels PlainMeds reads (4) do not name darifenacin. The darifenacin label: “No dosing adjustments are recommended in the presence of CYP2D6 inhibitors.”
Check it at the source: the darifenacin FDA label on DailyMed (effective February 10, 2026, Torrent Pharmaceuticals Limited); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the darifenacin label say about paroxetine?
Darifenacin label, drug interactionsNo dosing adjustments are recommended in the presence of CYP2D6 inhibitors (for example, paroxetine, fluoxetine, quinidine and duloxetine) [see Clinical Pharmacology (12.3)].
Source: FDA drug label (Darifenacin), Torrent Pharmaceuticals Limited, effective February 10, 2026 (SPL set e84f1ae3-b9a2-4a15-a299-c75373891cc1), via openFDA; the full label on DailyMed
What does the paroxetine label say about darifenacin?
Paroxetine's label (effective February 12, 2026) and its 3 other brand-application labels do not name darifenacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darifenacin | Paroxetine | |
|---|---|---|
| Labeled for | Overactive bladder | Depression, Anxiety, Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.432 per tablet 15 mg tablet | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once