Darifenacin and Paroxetine Interaction
Drug interaction information between Darifenacin and Paroxetine.
Darifenacin and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darifenacin and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine slows down the liver enzyme that processes darifenacin. This may result in darifenacin staying in your body slightly longer than usual.
FDA Label Information
7.2 CYP2D6 Inhibitors No dosing adjustments are recommended in the presence of CYP2D6 inhibitors (for example, paroxetine, fluoxetine, quinidine and duloxetine) [see Clinical Pharmacology (12.3) ] .
Darifenacin Also Interacts With
- Thioridazine moderate
- Flecainide moderate
- Itraconazole moderate
- Fluoxetine minor
- Duloxetine minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Darifenacin + Paroxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Darifenacin's 18. In the minor band specifically: Darifenacin has 15 (also Fluoxetine, Duloxetine, Estradiol, Diltiazem); Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine).
What mechanism field is on file for Darifenacin and Paroxetine?
Paroxetine slows down the liver enzyme that processes darifenacin. This may result in darifenacin staying in your body slightly longer than usual.
Paroxetine carries more major-labeled pairs than Darifenacin
SPL source-record counts only. This page's band is minor · classes on file: Darifenacin (Anticholinergic (Overactive Bladder)); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Darifenacin's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Darifenacin
- Fluoxetine
- Duloxetine
- Estradiol
- Diltiazem
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.