Darifenacin and Diltiazem Interaction
Drug interaction information between Darifenacin and Diltiazem.
Darifenacin and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darifenacin and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem interferes with a liver protein that breaks down darifenacin. This can cause a minor increase in darifenacin levels in your body.
FDA Label Information
No dosing adjustments are recommended in the presence of moderate CYP3A4 inhibitors (for example, erythromycin, fluconazole, diltiazem and verapamil) [see Dosage and Administration (2) and Clinical Pharmacology (12.3) ] .
Darifenacin Also Interacts With
- Thioridazine moderate
- Flecainide moderate
- Itraconazole moderate
- Fluoxetine minor
- Duloxetine minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Darifenacin + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Darifenacin's 18. In the minor band specifically: Darifenacin has 15 (also Fluoxetine, Duloxetine, Estradiol, Paroxetine); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Darifenacin and Diltiazem?
Diltiazem interferes with a liver protein that breaks down darifenacin. This can cause a minor increase in darifenacin levels in your body.
Diltiazem carries more major-labeled pairs than Darifenacin
SPL source-record counts only. This page's band is minor · classes on file: Darifenacin (Anticholinergic (Overactive Bladder)); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Darifenacin's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Darifenacin
- Fluoxetine
- Duloxetine
- Estradiol
- Paroxetine
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.