What the FDA labels say about taking them together
Darifenacin and fluoxetine
Darifenacin's FDA label of February 10, 2026 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name darifenacin. The darifenacin label: “No dosing adjustments are recommended in the presence of CYP2D6 inhibitors.”
Check it at the source: the darifenacin FDA label on DailyMed (effective February 10, 2026, Torrent Pharmaceuticals Limited); the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company).
What does the darifenacin label say about fluoxetine?
Darifenacin label, drug interactionsNo dosing adjustments are recommended in the presence of CYP2D6 inhibitors (for example, paroxetine, fluoxetine, quinidine and duloxetine) [see Clinical Pharmacology (12.3)].
Source: FDA drug label (Darifenacin), Torrent Pharmaceuticals Limited, effective February 10, 2026 (SPL set e84f1ae3-b9a2-4a15-a299-c75373891cc1), via openFDA; the full label on DailyMed
What does the fluoxetine label say about darifenacin?
Fluoxetine's label (effective January 8, 2026) does not name darifenacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darifenacin | Fluoxetine | |
|---|---|---|
| Labeled for | Overactive bladder | Depression, Anxiety, Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.432 per tablet 15 mg tablet | $0.0519 per capsule 40 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once