Darifenacin and Fluoxetine Interaction
Drug interaction information between Darifenacin and Fluoxetine.
Darifenacin and Fluoxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Darifenacin and Fluoxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluoxetine slows down the liver's ability to break down darifenacin. This might cause a small increase in the amount of darifenacin in your system.
FDA Label Information
7.2 CYP2D6 Inhibitors No dosing adjustments are recommended in the presence of CYP2D6 inhibitors (for example, paroxetine, fluoxetine, quinidine and duloxetine) [see Clinical Pharmacology (12.3) ] .
Darifenacin Also Interacts With
- Thioridazine moderate
- Flecainide moderate
- Itraconazole moderate
- Duloxetine minor
- Estradiol minor
Fluoxetine Also Interacts With
- Aspirin major
- Warfarin major
- Olanzapine major
- Pimozide major
- Thioridazine major
Frequently Asked Questions
What SPL severity band is on file for Darifenacin + Fluoxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluoxetine has 68 labeled pairs on file vs Darifenacin's 18. In the minor band specifically: Darifenacin has 15 (also Duloxetine, Estradiol, Paroxetine, Diltiazem); Fluoxetine has 43 (also Ketoconazole, Lithium, Moxifloxacin, Erythromycin).
What mechanism field is on file for Darifenacin and Fluoxetine?
Fluoxetine slows down the liver's ability to break down darifenacin. This might cause a small increase in the amount of darifenacin in your system.
Fluoxetine carries more major-labeled pairs than Darifenacin
SPL source-record counts only. This page's band is minor · classes on file: Darifenacin (Anticholinergic (Overactive Bladder)); Fluoxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Fluoxetine has 6 major-labeled pairs vs Darifenacin's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
- Other minor peers for Darifenacin
- Duloxetine
- Estradiol
- Paroxetine
- Diltiazem
6 major · 19 moderate · 43 minor · 68 total
- Other minor peers for Fluoxetine
- Ketoconazole
- Lithium
- Moxifloxacin
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.