Darifenacin and Itraconazole Interaction
Drug interaction information between Darifenacin and Itraconazole.
Darifenacin and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Darifenacin and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole interferes with the enzymes that remove darifenacin from your body, leading to higher levels of the drug in your blood. This increase can make you more likely to experience side effects.
FDA Label Information
Darifenacin Vardenafil Not recommended during and 2 weeks after itraconazole treatment.
Darifenacin Also Interacts With
- Thioridazine moderate
- Flecainide moderate
- Fluoxetine minor
- Duloxetine minor
- Estradiol minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Darifenacin + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Darifenacin's 18. In the moderate band specifically: Darifenacin has 3 (also Thioridazine, Flecainide); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Darifenacin and Itraconazole?
Itraconazole interferes with the enzymes that remove darifenacin from your body, leading to higher levels of the drug in your blood. This increase can make you more likely to experience side effects.
Itraconazole carries more major-labeled pairs than Darifenacin
SPL source-record counts only. This page's band is moderate · classes on file: Darifenacin (Anticholinergic (Overactive Bladder)); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Darifenacin's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 15 minor · 18 total
- Other moderate peers for Darifenacin
- Thioridazine
- Flecainide
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.