Dapagliflozin and Simvastatin Interaction
Drug interaction information between Dapagliflozin and Simvastatin.
Dapagliflozin and Simvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dapagliflozin and Simvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not significantly change how the body processes each other.
FDA Label Information
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Dapagliflozin Also Interacts With
- Metformin minor
- Hydrochlorothiazide minor
- Glimepiride minor
- Valsartan minor
- Warfarin minor
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Frequently Asked Questions
What SPL severity band is on file for Dapagliflozin + Simvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Dapagliflozin's 13. In the minor band specifically: Dapagliflozin has 13 (also Metformin, Hydrochlorothiazide, Glimepiride, Valsartan); Simvastatin has 21 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Dapagliflozin and Simvastatin?
These drugs do not significantly change how the body processes each other.
Simvastatin carries more major-labeled pairs than Dapagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Dapagliflozin (SGLT2 Inhibitor); Simvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Simvastatin has 11 major-labeled pairs vs Dapagliflozin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 13 minor · 13 total
- Other minor peers for Dapagliflozin
- Metformin
- Hydrochlorothiazide
- Glimepiride
- Valsartan
11 major · 9 moderate · 21 minor · 41 total
- Other minor peers for Simvastatin
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.