What the FDA labels say about taking them together
Dapagliflozin and glimepiride
Dapagliflozin's FDA label of June 3, 2026 names glimepiride in its drug interactions section; the glimepiride label PlainMeds reads does not name dapagliflozin. The dapagliflozin label: “Coadministered Drug (Dose Regimen) Single dose unless otherwise noted.: Glimepiride (4 mg); Dapagliflozin (Dose Regimen): 20 mg; Effect on Dapagliflozin Exposure [% Change (90% CI)]: ↔; ↔”
Check it at the source: the dapagliflozin FDA label on DailyMed (effective June 3, 2026, AstraZeneca Pharmaceuticals LP); the glimepiride FDA label on DailyMed (effective May 12, 2025, Micro Labs Limited).
What does the dapagliflozin label say about glimepiride?
Dapagliflozin label, drug interactionsCoadministered Drug (Dose Regimen) Single dose unless otherwise noted.: Glimepiride (4 mg); Dapagliflozin (Dose Regimen): 20 mg; Effect on Dapagliflozin Exposure [% Change (90% CI)]: ↔; ↔
Source: FDA drug label (FARXIGA), AstraZeneca Pharmaceuticals LP, effective June 3, 2026 (SPL set 72ad22ae-efe6-4cd6-a302-98aaee423d69), via openFDA; the full label on DailyMed
What does the glimepiride label say about dapagliflozin?
Glimepiride's label (effective May 12, 2025) does not name dapagliflozin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Glimepiride), Micro Labs Limited, effective May 12, 2025 (SPL set 60e9397e-83b9-489e-9683-6f87e458bbaa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dapagliflozin | Glimepiride | |
|---|---|---|
| Labeled for | Chronic kidney disease, Heart failure, Type 2 diabetes | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.184 per tablet 10 mg tablet | $0.0507 per tablet 4 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once