Dapagliflozin and Valsartan Interaction
Drug interaction information between Dapagliflozin and Valsartan.
Dapagliflozin and Valsartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dapagliflozin and Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is a slight change in drug levels, but it is not large enough to affect how the medicine works.
FDA Label Information
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Dapagliflozin Also Interacts With
- Metformin minor
- Hydrochlorothiazide minor
- Simvastatin minor
- Glimepiride minor
- Warfarin minor
Valsartan Also Interacts With
- Sacubitril/Valsartan major
- Aliskiren major
- Lithium moderate
- Spironolactone minor
- Amiloride minor
Frequently Asked Questions
What SPL severity band is on file for Dapagliflozin + Valsartan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dapagliflozin has 13 labeled pairs on file vs Valsartan's 8. In the minor band specifically: Dapagliflozin has 13 (also Metformin, Hydrochlorothiazide, Simvastatin, Glimepiride); Valsartan has 5 (also Spironolactone, Amiloride, Amlodipine/Valsartan, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Dapagliflozin and Valsartan?
There is a slight change in drug levels, but it is not large enough to affect how the medicine works.
Valsartan carries more major-labeled pairs than Dapagliflozin
SPL source-record counts only. This page's band is minor · classes on file: Dapagliflozin (SGLT2 Inhibitor); Valsartan (Angiotensin II Receptor Blocker (ARB)).
Valsartan has 2 major-labeled pairs vs Dapagliflozin's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 13 minor · 13 total
- Other minor peers for Dapagliflozin
- Metformin
- Hydrochlorothiazide
- Simvastatin
- Glimepiride
2 major · 1 moderate · 5 minor · 8 total
- Other minor peers for Valsartan
- Spironolactone
- Amiloride
- Amlodipine/Valsartan
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.