Dapagliflozin and Hydrochlorothiazide Interaction
Drug interaction information between Dapagliflozin and Hydrochlorothiazide.
Dapagliflozin and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dapagliflozin and Hydrochlorothiazide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs do not have a meaningful effect on each other's levels in the body.
What To Do
You can take these medicines together without changing your dose.
FDA Label Information
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Dapagliflozin Also Interacts With
- Metformin minor
- Simvastatin minor
- Glimepiride minor
- Valsartan minor
- Warfarin minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
Can I take Dapagliflozin and Hydrochlorothiazide together?
This is a minor interaction. You can take these medicines together without changing your dose.
How serious is the interaction between Dapagliflozin and Hydrochlorothiazide?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Dapagliflozin and Hydrochlorothiazide interact?
These two drugs do not have a meaningful effect on each other's levels in the body.
Understanding the Dapagliflozin and Hydrochlorothiazide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Dapagliflozin belongs to the SGLT2 Inhibitor class and Hydrochlorothiazide belongs to the Thiazide Diuretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs do not have a meaningful effect on each other's levels in the body. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Dapagliflozin has 13 total documented interactions on file in this dataset, and Hydrochlorothiazide has 31. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can take these medicines together without changing your dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Dapagliflozin or Hydrochlorothiazide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.