Prescription medication · SGLT2 Inhibitor
dapagliflozin
Also sold as Farxiga. This medicine can help adults with chronic kidney disease by reducing the risk of kidney problems, heart problems, and needing to go to the hospital for heart failure.
Data updated 2026-05-15
- 50,521
- FDA reportsOften reported
- 13
- InteractionsSeveral interactions
- 39% less
- Generic vs brandReal savings
- $18.63
- Brand price (NADAC)
What the data shows
dapagliflozin (Farxiga) is a prescription SGLT2 Inhibitor, reported at a middle-of-the-pack volume (50,521 FDA reports), with a lower-cost generic available (39% less than brand).
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
dapagliflozin (Farxiga) is a prescription SGLT2 Inhibitor. This medicine can help adults with chronic kidney disease by reducing the risk of kidney problems, heart problems, and needing to go to the hospital for heart failure.
Dapagliflozin (Farxiga) helps lower blood sugar in adults with type 2 diabetes. It also helps adults with heart failure or chronic kidney disease.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$18.63/unit
Generic Price
$11.38/unit
Generic Savings
39%
Generic Available
Yes (0 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
This medicine can help adults with chronic kidney disease by reducing the risk of kidney problems, heart problems, and needing to go to the hospital for heart failure.
Common side effects
Yeast infections of the vagina, Common cold, Urinary tract infections
Key warnings
Dapagliflozin can cause a serious condition called diabetic ketoacidosis (DKA), especially if you have type 1 diabetes.
The sections below are summarized in plain English from dapagliflozin's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Dapagliflozin is a type of medicine called an SGLT2 inhibitor. It works in the kidneys to remove extra sugar from your body through your urine. This helps to lower your blood sugar levels.
How to Take It
Take dapagliflozin once a day by mouth. If you are taking it for blood sugar control, your doctor may start you on 5 mg or 10 mg. For other conditions, the usual dose is 10 mg daily. You can take it with or without food.
This is a plain-language summary of dapagliflozin's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
This medicine may harm your unborn baby, especially during the second and third trimesters. It is not recommended while breastfeeding.
This is a plain-language summary of dapagliflozin's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the regular time.
This is a plain-language summary of dapagliflozin's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store dapagliflozin at room temperature, away from moisture and heat.
Side Effects (from patient reports)
Based on 50,521 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for dapagliflozin, by number of reports
- Death
Death
7,017 reports
- Tiredness 2,250
Tiredness
2,250 reports
- Feeling sick to your stomach 2,218
Feeling sick to your stomach
2,218 reports
- Feeling lightheaded 2,096
Feeling lightheaded
2,096 reports
- Loose stools 2,074
Loose stools
2,074 reports
- Difficulty breathing 1,970
Difficulty breathing
1,970 reports
- High blood sugar 1,862
High blood sugar
1,862 reports
- Weight loss 1,827
Weight loss
1,827 reports
- Sudden kidney damage 1,699
Sudden kidney damage
1,699 reports
- Throwing up 1,621
Throwing up
1,621 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for dapagliflozin each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where dapagliflozin sits
dapagliflozin has more FDA adverse-event reports than 73% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is dapagliflozin; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 50,521 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2008–2025.
Total Reports
50,521
Reports Mentioning Death
8,602
17.0% of reports — not proof of cause
Hospitalization Reports
14,338
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | DEATH | 7,017 |
| 2 | FATIGUE | 2,250 |
| 3 | NAUSEA | 2,218 |
| 4 | DIZZINESS | 2,096 |
| 5 | DIARRHOEA | 2,074 |
| 6 | DYSPNOEA | 1,969 |
| 7 | BLOOD GLUCOSE INCREASED | 1,861 |
| 8 | WEIGHT DECREASED | 1,827 |
| 10 | ACUTE KIDNEY INJURY | 1,699 |
| 11 | VOMITING | 1,621 |
| 12 | DIABETIC KETOACIDOSIS | 1,524 |
| 13 | HEADACHE | 1,479 |
| 14 | PAIN | 1,372 |
| 15 | MALAISE | 1,368 |
| 16 | FUNGAL INFECTION | 1,352 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Dapagliflozin can cause a serious condition called diabetic ketoacidosis (DKA), especially if you have type 1 diabetes. Symptoms include nausea, vomiting, stomach pain, and trouble breathing. If you have these symptoms, stop taking this medicine and get medical help right away. This medicine can also cause serious infections in the area between your genitals and anus. Get medical help right away if you have pain, tenderness, redness, or swelling in this area, along with a fever or feeling unwell.
Known Drug Interactions
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Mechanism: These two drugs do not have a meaningful effect on each other's levels in the body.
What to do: You can take these medicines together without changing your dose.
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Mechanism: These two drugs do not have a meaningful effect on each other's levels in the body.
What to do: You can take these medicines together without changing your dose.
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Mechanism: These drugs do not significantly change how the body processes each other.
What to do: No dose adjustments are required for this combination.
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Mechanism: These medicines do not have a meaningful effect on each other's levels in your system.
What to do: You do not need to change your dose when taking these medicines together.
No dosing adjustments required for the following: Oral Antidiabetic Agents Metformin (1000 mg) 20 mg ↔ ↔ Pioglitazone (45 mg) 50 mg ↔ ↔ Sitagliptin (100 mg) 20 mg ↔ ↔ Glimepiride (4 mg) 20 mg ↔ ↔ Voglibose (0.2 mg three times daily) 10 mg ↔ ↔ Other Medications Hydrochlorothiazide (25 mg) 50 mg ↔ ↔ Bumetanide (1 mg) 10 mg once daily for 7 days ↔ ↔ Valsartan (320 mg) 20 mg ↓12% [↓3%, ↓20%] ↔ Simvastatin (40 mg) 20 mg ↔ ↔ Anti-infective Agent Rifampin (600 mg once daily for 6 days) 10 mg ↓7% [↓22%, ↑11%] ↓22% [↓27%, ↓17%] Nonsteroidal Anti-inflammatory Agent Mefenamic Acid (loading dose of...
Mechanism: There is a slight change in drug levels, but it is not large enough to affect how the medicine works.
What to do: Your doctor does not need to adjust your dosage for this combination.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
Can I take dapagliflozin if I have type 1 diabetes?
What should I do if I think I have ketoacidosis?
Can dapagliflozin cause low blood sugar?
Do I need to adjust my insulin dose when taking dapagliflozin?
Can dapagliflozin affect my kidneys?
Should I stop taking dapagliflozin before surgery?
Can dapagliflozin affect other medicines I am taking?
How will I know if dapagliflozin is working?
What if I get a urinary tract infection while taking this medicine?
Can dapagliflozin cause weight loss?
What are the common side effects of dapagliflozin?
Does dapagliflozin interact with other medications?
What drug class is dapagliflozin?
Is there a generic version of dapagliflozin?
Is dapagliflozin safe during pregnancy?
Related Medications in SGLT2 Inhibitor
Other drugs grouped near dapagliflozin - same-class peers and common alternatives.
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Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for dapagliflozin
The FDA label for dapagliflozin (sold under brand names such as Farxiga) classifies it as a prescription-only medication in the SGLT2 Inhibitor class. This medicine can help adults with chronic kidney disease by reducing the risk of kidney problems, heart problems, and needing to go to the hospital for heart failure. Official labeling lists 3 commonly reported side effects, including Yeast infections of the vagina, Common cold, Urinary tract infections.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 50,521 voluntary reports. The database also lists 13 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated minor severity. NADAC pricing from CMS shows a generic unit cost of $11.38 versus $18.63 for the brand - a 39% generic savings.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: December 12, 2023
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages