Clobazam and Lisdexamfetamine Interaction
Drug interaction information between Clobazam and Lisdexamfetamine.
Clobazam and Lisdexamfetamine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clobazam and Lisdexamfetamine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Lisdexamfetamine does not interfere with the liver enzymes that process clobazam.
FDA Label Information
From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g., theophylline, duloxetine, melatonin), CYP2D6 (e.g., atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g., omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g., midazolam, pimozide, simvastatin) is necessary when VYVANSE is co-administered [see Clinical Pharmacology (12.3) ] .
Clobazam Also Interacts With
- Cannabidiol moderate
- Cenobamate moderate
- Omeprazole minor
- Fluconazole minor
- Fluvoxamine minor
Lisdexamfetamine Also Interacts With
- Omeprazole minor
- Simvastatin minor
- Duloxetine minor
- Venlafaxine minor
- Atomoxetine minor
Frequently Asked Questions
What SPL severity band is on file for Clobazam + Lisdexamfetamine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lisdexamfetamine has 14 labeled pairs on file vs Clobazam's 6. In the minor band specifically: Clobazam has 4 (also Omeprazole, Fluconazole, Fluvoxamine); Lisdexamfetamine has 14 (also Omeprazole, Simvastatin, Duloxetine, Venlafaxine).
What mechanism field is on file for Clobazam and Lisdexamfetamine?
Lisdexamfetamine does not interfere with the liver enzymes that process clobazam.
Lisdexamfetamine's labeled portfolio outnumbers Clobazam
SPL source-record counts only. This page's band is minor · classes on file: Clobazam (Benzodiazepine (Anticonvulsant)); Lisdexamfetamine (CNS Stimulant).
0 major · 2 moderate · 4 minor · 6 total
- Other minor peers for Clobazam
- Omeprazole
- Fluconazole
- Fluvoxamine
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Lisdexamfetamine
- Omeprazole
- Simvastatin
- Duloxetine
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.